Thiamine EP Impurity B HBr CAS CATO-C4X-187313
| CAS No. | CATO-C4X-187313 |
| Molecular Formula | C11H15N4OS |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Thiamine EP Impurity B HBr (CAS CATO-C4X-187313, C11H15N4OSHBrBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H15N4OSHBrBr, Thiamine EP Impurity B HBr contains a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 412.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H15N4OS HBr Br |
| Molecular Weight | 412.14 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Thiamine Standards
- Thiamine Impurity 30 (CAS 100502-51-0)
- Thiamine Nitrate EP Impurity G (CAS 1037-29-2)
- Thiamine Impurity 11 (CAS 105070-51-7)
- Thiamine /Vitamin B1 Impurity 50 (CAS 10553-88-5)
- Thiamine /Vitamin B1 Impurity 54 Ammonium Salt (CAS 10553-88-5 (free form))
- Thiamine EP Impurity F (CAS 10593-44-9)
- Thiamine disulfide (dinitrate) (CAS 109125-52-2)
- Thiamine Impurity 54 (CAS 1124-01-2)
Recommended Standards
- Cefdinir Impurity 34 (CAS 73150-67-1)
- Insulin Degludec impurity 4 (CAS CATO-C4X-21574)
- Isavuconazole Impurity 216 (CAS CATO-C4X-1236216)
- N-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,8-naphthyridine-2-carboxamide (CAS 2246773-81-7)
- 2-(4-Fluoro-3-methylbenzoyl)pyridine (CAS 1261658-89-2)
- (S)-2-(Aminomethyl)-1-Cbz-pyrrolidine (CAS 141774-68-7)
- Methyl 4-(1,2,3,4-Tetrahydronaphthalen-6-yl)-2,4-dioxobutanoate (CAS 1159981-06-2)
- 2-(Diphenylphosphoryl)succinonitrile (CAS 922729-84-8)
- 1-[(4-fluorophenyl)methyl]cyclopentan-1-amine (CAS 757136-24-6)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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