Thiamine Nitrate EP Impurity A （Hemisulfate） CAS CATO-C4X-187323
| CAS No. | CATO-C4X-187323 |
| Molecular Formula | 2*C12H16N4O4S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Thiamine Nitrate EP Impurity A （Hemisulfate）.
As a process- or degradation-related impurity, Thiamine Nitrate EP Impurity A （Hemisulfate） (CAS CATO-C4X-187323, C12H16N4O4S2H2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Thiamine Nitrate EP Impurity A （Hemisulfate） is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 442.48 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Thiamine Nitrate EP Impurity A （Hemisulfate） meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C12H16N4O4S2 H2O4S |
| Molecular Weight | 442.48 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 3 |
Related Thiamine Standards
- Thiamine Impurity 30 (CAS 100502-51-0)
- Thiamine Nitrate EP Impurity G (CAS 1037-29-2)
- Thiamine Impurity 11 (CAS 105070-51-7)
- Thiamine /Vitamin B1 Impurity 50 (CAS 10553-88-5)
- Thiamine /Vitamin B1 Impurity 54 Ammonium Salt (CAS 10553-88-5 (free form))
- Thiamine EP Impurity F (CAS 10593-44-9)
- Thiamine disulfide (dinitrate) (CAS 109125-52-2)
- Thiamine Impurity 54 (CAS 1124-01-2)
Recommended Standards
- Orforglipron Impurity 7 (CAS CATO-C4X-32347)
- Telmisartan Impurity 87 (CAS CATO-C4X-135987)
- Posaconazole impurity 241 (CAS CATO-C4X-1208241)
- N,N'-([1,2,5]Oxadiazolo[3,4-d]pyrimidine-5,7-diyl)dibenzamide (CAS 68152-16-9)
- tert-Butyl (3-amino-1,1,1-trifluoropropan-2-yl)carbamate (CAS 1429913-34-7)
- (4-(4-Bromophenyl)-1,1-dioxido-4H-benzo[b][1,4]thiazin-2-yl)(pyrrolidin-1-yl)methanone (CAS 1251624-24-4)
- Tert-butyl 3-(3,6-dichloropyridazin-4-yl)pyrrolidine-1-carboxylate (CAS 2306270-58-4)
- N-(2-(1-benzyl-2-methyl-1H-indol-3-yl)ethyl)acetamide (CAS 337506-29-3)
- 2-[amino(4-pyridinyl)methylene]malononitrile (CAS 338750-87-1)
- Neuropeptide Y, human (CAS 98264-90-5)
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