Osimertinib Impurity 4 (AZD2015) CAS CATO-C4X-20455
| CAS No. | CATO-C4X-20455 |
| Molecular Formula | C33H41ClN8O3 |
| Molecular Weight | 633.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Osimertinib Impurity 4 (AZD2015) (CAS CATO-C4X-20455) is a certified pharmaceutical impurity reference standard with the molecular formula C33H41ClN8O3 and a molecular weight of 633.19 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Osimertinib Impurity 4 (AZD2015) is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 633.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H41ClN8O3 |
| Molecular Weight | 633.19 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Osimertinib Standards
- Osimertinib Impurity 71 (CAS CATO-C4X-204571)
- Osimertinib Impurity 85 (CAS CATO-C4X-204585)
- Osimertinib Impurity 79 (CAS CATO-C4X-204579)
- Osimertinib impurity 59 (CAS CATO-C4X-204559)
- Osimertinib Impurity 97 (CAS CATO-C4X-204597)
- Osimertinib Impurity 86 (CAS CATO-C4X-204586)
- Osimertinib Impurity 117 (CAS CATO-C4X-2045117)
- Osimertinib impurity 58 (CAS CATO-C4X-204558)
Recommended Standards
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