Linaclotide Impurity 27 CAS CATO-C4X-210627
| CAS No. | CATO-C4X-210627 |
| Molecular Formula | C59H79N15O21S6 |
| Molecular Weight | 1526.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Linaclotide Impurity 27.
As a process- or degradation-related impurity, Linaclotide Impurity 27 (CAS CATO-C4X-210627, C59H79N15O21S6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Linaclotide Impurity 27 (C59H79N15O21S6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 28.0, corresponding to approximately 28 ring(s) or double-bond equivalent(s). With a molecular weight of 1526.73 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C59H79N15O21S6 |
| Molecular Weight | 1526.73 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 28.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 15 |
| Sulfur Atoms | 6 |
Related Linaclotide Standards
- Linaclotide Impurity 18 (CAS CATO-C4X-210618)
- Linaclotide Impurity 19 (CAS CATO-C4X-210619)
- Linaclotide Impurity 20 (CAS CATO-C4X-210620)
- Linaclotide Impurity 21 (CAS CATO-C4X-210621)
- Linaclotide Impurity 22 (CAS CATO-C4X-210622)
- Linaclotide Impurity 23 (CAS CATO-C4X-210623)
- Linaclotide Impurity 24 (CAS CATO-C4X-210624)
- Linaclotide Impurity 25 (CAS CATO-C4X-210625)
Recommended Standards
- Linaclotide Impurity 26 (CAS CATO-C4X-210626)
- Linaclotide Impurity 28 (CAS CATO-C4X-210628)
- Linaclotide Impurity 29 (CAS CATO-C4X-210629)
- Linaclotide Impurity 30 (CAS CATO-C4X-210630)
- Clopidogrel Impurity 14 (CAS 5402-55-1)
- Argatroban Impurity 6 ( (Mixture of Diastereomers) (CAS 189264-04-8)
- Metronidazole Impurity 12 (CAS CATO-C4X-140512)
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