Roxadustat Impurity 167 CAS CATO-C4X-2213167
| CAS No. | CATO-C4X-2213167 |
| Molecular Formula | C36H28N2O8 |
| Molecular Weight | 616.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Roxadustat Impurity 167 (C36H28N2O8) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Roxadustat Impurity 167 (CAS CATO-C4X-2213167, C36H28N2O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Roxadustat Impurity 167 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C36H28N2O8 |
| Molecular Weight | 616.62 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Roxadustat Standards
- Roxadustat Impurity 61 (CAS CATO-C4X-221361)
- Roxadustat Impurity 119 (CAS CATO-C4X-2213119)
- Roxadustat Impurity 37 (CAS CATO-C4X-221337)
- Roxadustat Impurity 56 (CAS CATO-C4X-221356)
- Roxadustat Impurity 59 (CAS CATO-C4X-221359)
- Roxadustat Impurity 75 (CAS CATO-C4X-221375)
- Roxadustat Impurity 93 (CAS CATO-C4X-221393)
- Roxadustat Impurity 144 (CAS CATO-C4X-2213144)
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