Baricitinib Impurity 51 CAS CATO-C4X-226051
| CAS No. | CATO-C4X-226051 |
| Molecular Formula | C16H17N7O2S |
| Molecular Weight | 371.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Baricitinib Impurity 51 (C16H17N7O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 371.42 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Baricitinib Impurity 51 (CAS CATO-C4X-226051, C16H17N7O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17N7O2S |
| Molecular Weight | 371.42 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Baricitinib Standards
- Baricitinib (CAS 1187594-09-7)
- Baricitinib Impurity 100 (CAS CATO-C4X-2260100)
- Baricitinib Impurity 71 (CAS CATO-C4X-226071)
- Baricitinib Impurity 91 (CAS CATO-C4X-226091)
- Baricitinib Impurity 39 (CAS 1146629-76-6)
- Baricitinib-D3 (CAS 1564242-30-3)
- Baricitinib Impurity 58 (CAS CATO-C4X-226058)
- Baricitinib D5 (CAS CATO-C4X-2260107)
Recommended Standards
- N-(2,4-Difluorophenyl)-2-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}acetamide (CAS 329080-39-9)
- Boc-D-Tyr(Bzl)-OH (CAS 63769-58-4)
- Lenperone (CAS 24678-13-5)
- Methyl 3-methyl-1-(4-methylbenzyl)-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011399-01-1)
- Glimepiride EP Impurity J (CAS 41176-98-1)
- Venetoclax Impurity 59 (CAS CATO-C4X-249559)
- Loteprednol Impurity 8 (CAS 129260-79-3)
- Famciclovir Impurity 8 (CAS 126589-69-3)
- 5,6-Dimethyl-2-[2-oxo-2-(piperidin-1-yl)ethyl]-2,3-dihydropyridazin-3-one (CAS 2199765-17-6)
- 2-Amino-6-(cyclohexyloxy)phenol (CAS 1243393-82-9)
- 4-(3,5-Dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)benzoic acid (CAS 18510-65-1)
- 1-Phenyl-5-(pyridin-2-yl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 947271-61-6)
- 6-((1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino)-3,4-dihydroquinolin-2(1H)-one (CAS 1157388-84-5)
- Hexapeptide-1 (CAS CATO-CPTD788821)
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