CMC2026 Impurity 5 CAS CATO-C4X-22665
| CAS No. | CATO-C4X-22665 |
| Molecular Formula | C26H28ClF4N3O2 |
| Molecular Weight | 525.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of CMC2026 Impurity 5 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies CMC2026 Impurity 5 (CAS CATO-C4X-22665), a pharmacopoeial impurity reference standard (molecular formula C26H28ClF4N3O2, MW 525.97 g/mol) used for the identification and quantification of trace impurities in APIs.
CMC2026 Impurity 5 (C26H28ClF4N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), CMC2026 Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H28ClF4N3O2 |
| Molecular Weight | 525.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- Fruquintinib Impurity 1 (CAS CATO-C4X-30371)
- 1,1,2,2-Tetrafluoro-2-(1,1,2,2,3,3,4,4-octafluoro-4-iodobutoxy)ethane-1-sulfonyl fluoride (CAS 67990-76-5)
- 1-(2-(2-Chloro-6H-indolo[2,3-b]quinoxalin-6-yl)acetyl)-4-(4-hydroxy-3-methoxybenzylidene)-3-methyl-1H-pyrazol-5(4H)-one (CAS 119457-16-8)
- Bosentan USP Related Compound A (CAS 150727-06-3)
- Cholic Acid Impurity 24 (CAS 15173-22-5)
- Dotinurad Impurity 4 (CAS 1285573-47-8)
- Salicylic Acid Impurity 23 (CAS CATO-C4X-190223)
- 4,6-Dibromoindoline (CAS 1956318-31-2)
- (S)-3-Amino-3-(4-hydroxyphenyl)propanoic acid hydrochloride (CAS 54732-46-6)
- 2-{[(3-bromo-4-methylphenyl)amino]methyl}phenol (CAS 306732-31-0)
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)benzaldehyde (CAS 1112209-48-9)
- 2-((4-Butylphenyl)amino)-3-chloronaphthalene-1,4-dione (CAS 179115-42-5)
- Canagliflozin Impurity 6 (CAS CATO-C4X-11236)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
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