Niraparib Impurity 18 HCl CAS CATO-C4X-232918
| CAS No. | CATO-C4X-232918 |
| Molecular Formula | C22H30N4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Niraparib Impurity 18 HCl is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Niraparib Impurity 18 HCl (CAS CATO-C4X-232918, C22H30N4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Niraparib Impurity 18 HCl (C22H30N4HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 386.97 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H30N4 HCl |
| Molecular Weight | 386.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Niraparib Standards
- Niraparib R-enantiomer p-tosylate (CAS 1038915-58-0)
- Niraparib (CAS 1038915-60-4)
- Niraparib-d5 (CAS 1038915-60-4 (non-labelled))
- Niraparib hydrochloride (CAS 1038915-64-8)
- Niraparib Tosylate (CAS 1038915-73-9)
- Niraparib Impurity N1 (CAS 1038915-75-1)
- Niraparib Impurity N19 (CAS 1038916-08-3)
- Niraparib Impurity 56 (CAS 1090871-88-7)
Recommended Standards
- Orlistat impurity 33 (CAS CATO-C4X-149933)
- Butylphthalide Impurity 72 (CAS 1225206-61-0)
- Formoterol impurity 124 (CAS CATO-C4X-1525124)
- 1,4-Dimethoxy-2-(4-nitrostyryl)benzene (CAS 5529-38-4)
- 10-Amino-1,3,4,10b-tetrahydropyrido[2,1-a]isoindole-2,6-dione (CAS 1245654-43-6)
- 2-Thio 2-Deoxyuridine (CAS 35059-12-2)
- 4-Methyl-3-(trifluoromethyl)benzamide (CAS 261952-00-5)
- (1,3-Bis(2,6-diisopropylphenyl)-2,3-dihydro-1H-imidazol-2-yl)(1-(tert-butyl)-1H-inden-2-yl)chloropalladate(II) (CAS 1779569-04-8)
- 5-Ethyl 6-methyl-2,5-pyridinedicarboxylate (CAS 890302-07-5)
- Semaglutide impurity 255 (CAS CATO-C4X-2226255)
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