Drotaverin Impurity 53 CAS CATO-C4X-243553
| CAS No. | CATO-C4X-243553 |
| Molecular Formula | C16H15NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Drotaverin Impurity 53 (CAS CATO-C4X-243553, C16H15NO4HBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Drotaverin Impurity 53 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 366.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Drotaverin Impurity 53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15NO4 HBr |
| Molecular Weight | 366.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Drotaverin Standards
- Drotaverin Impurity 48 (CAS 1536475-50-9)
- Drotaverin Impurity N2 (CAS 21088-15-3)
- Drotaverin Impurity 50 (CAS 5409-31-4)
- Drotaverin Impurity N1 (CAS 56046-20-9)
- Drotaverin Impurity 49 (CAS 854869-48-0)
- Drotaverin Impurity 45 (CAS 855199-57-4)
- Drotaverin Impurity 37 HBr (CAS CATO-C4X-243537)
- Drotaverin Impurity 38 (CAS CATO-C4X-243538)
Recommended Standards
- Cloxacillin Impurity 31 (CAS CATO-C4X-159731)
- Ezetimibe Impurity 97 (CAS 439113-83-4)
- Etoposide Impurity 32 (CAS CATO-C4X-202432)
- Methyl 2-(3-hydroxy-3-methylbutyl)-5-nitro-2H-indazole-7-carboxylate (CAS 2412105-01-0)
- 4-(Benzylsulfanyl)-6-(4-chlorophenyl)-2-(pyridin-4-yl)pyrimidine-5-carbonitrile (CAS 320418-10-8)
- 11-Cyano-N-(4-nitrophenyl)-9,10-dihydro-9,10-ethanoanthracene-11-carboxamide (CAS 312505-69-4)
- N-(2-Ethynylpyridin-3-yl)acetamide (CAS 1934655-99-8)
- Bisphenol A-d6 Diglycidyl Ether (CAS 1346600-09-6)
- Empagliflozin Impurity 27 (CAS CATO-C4X-106527)
- Hexapeptide-1 (CAS CATO-CPTD788821)
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