Amodiaquine Impurity 8 CAS CATO-C4X-24718

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.CATO-C4X-24718
Molecular FormulaC18H17ClN4O2
Molecular Weight356.81 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Amodiaquine Impurity 8 CAS CATO-C4X-24718 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 356.81 g/mol gives Amodiaquine Impurity 8 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Amodiaquine Impurity 8 (CAS CATO-C4X-24718), a pharmacopoeial impurity reference standard (molecular formula C18H17ClN4O2, MW 356.81 g/mol) used for the identification and quantification of trace impurities in APIs.

Amodiaquine Impurity 8 (C18H17ClN4O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Amodiaquine Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC18H17ClN4O2
Molecular Weight356.81 g/mol
AppearancePale yellow to yellow crystalline powder. (slight halide-like odor)
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)12.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
Halogen ContentCl-containing
Nitrogen Atoms4

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