Siponimod impurity 20 CAS CATO-C4X-247220
| CAS No. | CATO-C4X-247220 |
| Molecular Formula | C29H33F3N2O4 |
| Molecular Weight | 530.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Siponimod impurity 20 (CAS CATO-C4X-247220) is a certified pharmaceutical impurity reference standard with the molecular formula C29H33F3N2O4 and a molecular weight of 530.58 g/mol.
Structurally, Siponimod impurity 20 (C29H33F3N2O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 530.58 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H33F3N2O4 |
| Molecular Weight | 530.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Siponimod Standards
- Siponimod impurity 22 (CAS CATO-C4X-247222)
- Siponimod Impurity 38 (CAS CATO-C4X-247238)
- Siponimod Impurity 36 (CAS CATO-C4X-247236)
- Siponimod (CAS 1230487-00-9)
- Siponimod Impurity 30 (CAS CATO-C4X-247230)
- Siponimod Impurity 34 (CAS 2768181-14-0)
- Siponimod impurity 13 (CAS CATO-C4X-247213)
- Siponimod Impurity 37 (CAS CATO-C4X-247237)
Recommended Standards
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- Arbidol Impurity 51 (CAS 2062260-55-1)
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- 4,4,4-trifluorobutane-1-sulfonamide (CAS 1427379-30-3)
- 1',3'-Dihydro-[2,2'-biindenylidene]-1(3H)-one (CAS 5706-06-9)
- 2,2-Dimethyl-4-phenylbutanenitrile (CAS 75490-38-9)
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