Dotinurad impurity 111 CAS CATO-C4X-2494111
| CAS No. | CATO-C4X-2494111 |
| Molecular Formula | C29H22Cl4N2O4S2 |
| Molecular Weight | 668.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Dotinurad impurity 111 (CAS CATO-C4X-2494111, C29H22Cl4N2O4S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dotinurad impurity 111 (C29H22Cl4N2O4S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C29H22Cl4N2O4S2 |
| Molecular Weight | 668.44 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 2 |
Related Dotinurad Standards
- Dotinurad Impurity 91 (CAS CATO-C4X-249491)
- Dotinurad Impurity 15 (CAS CATO-C4X-249415)
- Dotinurad Impurity 47 (CAS CATO-C4X-249447)
- Dotinurad Impurity 59 (CAS CATO-C4X-249459)
- Dotinurad Impurity 58 (CAS CATO-C4X-249458)
- Dotinurad Impurity 134 (CAS CATO-C4X-2494134)
- Dotinurad Impurity 155 (CAS CATO-C4X-2494155)
- Dotinurad Impurity 173 (CAS CATO-C4X-2494173)
Recommended Standards
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- Ag (II) Protoporphyrin IX (CAS 80481-08-9)
- Ranitidine Impurity 17 (CAS CATO-C4X-137017)
- Vitamin K1 Impurity 11 (CAS CATO-C4X-220711)
- Salbutamol Impurity 67 (CAS CATO-C4X-117667)
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- 2-(2-(9H-Fluoren-9-ylidene)hydrazineyl)quinoline (CAS 330829-46-4)
- 1-(Benzo[d]thiazol-6-yl)imidazolidin-2-one (CAS 1260008-78-3)
- 2-(((2-Chlorothiazol-5-yl)methyl)(methyl)amino)ethanol (CAS 1353986-67-0)
- 3-Azaspiro[5.6]dodecane-2,4-dione (CAS 1078-89-3)
- 3-(Bromomethyl)-2-chloro-1,8-naphthyridine (CAS 1126424-63-2)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
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