Dotinurad Impurity 216 CAS CATO-C4X-2494216
| CAS No. | CATO-C4X-2494216 |
| Molecular Formula | C16H10Cl3NO3S |
| Molecular Weight | 402.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Dotinurad Impurity 216 (CAS CATO-C4X-2494216) is a certified pharmaceutical impurity reference standard with the molecular formula C16H10Cl3NO3S and a molecular weight of 402.68 g/mol.
Dotinurad Impurity 216 (C16H10Cl3NO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H10Cl3NO3S |
| Molecular Weight | 402.68 g/mol |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Dotinurad Standards
- Dotinurad Impurity 240 (CAS CATO-C4X-2494240)
- Dotinurad Impurity 223 (CAS CATO-C4X-2494223)
- Dotinurad Impurity 234 (CAS CATO-C4X-2494234)
- Dotinurad Impurity 235 (CAS CATO-C4X-2494235)
- Dotinurad Impurity 199 (CAS CATO-C4X-2494199)
- Dotinurad Impurity 205 (CAS CATO-C4X-2494205)
- Dotinurad Impurity 231 (CAS CATO-C4X-2494231)
- Dotinurad Impurity 196 (CAS CATO-C4X-2494196)
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