Dotinurad Impurity 42 CAS CATO-C4X-249442
| CAS No. | CATO-C4X-249442 |
| Molecular Formula | C10H11Cl2NO2 |
| Molecular Weight | 248.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dotinurad Impurity 42 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dotinurad Impurity 42 (CAS CATO-C4X-249442, C10H11Cl2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Dotinurad Impurity 42 (C10H11Cl2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H11Cl2NO2 |
| Molecular Weight | 248.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dotinurad Standards
- Dotinurad Impurity 143 (CAS CATO-C4X-2494143)
- Dotinurad Impurity 139 (CAS CATO-C4X-2494139)
- Dotinurad Impurity 213 (CAS CATO-C4X-2494213)
- Dotinurad Impurity 183 (CAS CATO-C4X-2494183)
- Dotinurad Impurity 144 (CAS 74953-20-1)
- Dotinurad Impurity 164 (CAS CATO-C4X-2494164)
- Dotinurad Impurity 54 (CAS CATO-C4X-249454)
- Dotinurad Impurity 63 (CAS CATO-C4X-249463)
Recommended Standards
- Ziprasidone impurity 52 (CAS CATO-C4X-124052)
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- 2-(5-Bromo-2-fluorophenyl)ethanethioamide (CAS 1016747-07-1)
- Arbidol Impurity 52 (CAS CATO-C4X-112952)
- Clindamycin Phosphas Impurity 45 (CAS 887402-22-4)
- Etelcalcetide impurity 38 (CAS CATO-C4X-324738)
- 1-Bromo-2-((hexyloxy)methyl)benzene (CAS 80171-38-6)
- 1-((3-Chlorophenoxy)methyl)-1H-pyrazol-4-amine (CAS 1002034-31-2)
- 4-(Aminomethyl)-3,4-dimethylhexan-3-ol (CAS 1522856-58-1)
- 4,5-Dimethyloxazolidin-2-one (CAS 58628-98-1)
- Tris-(2,2'-bipyridine) ruthenium (II) perchlorate (CAS 15635-95-7)
- 1-(5,6,7,8-Tetrahydro-1,6-naphthyridin-6-yl)prop-2-en-1-one (CAS 1179512-57-2)
- Peptide 439 (CAS CATO-CPTD788439)
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