Pitolisant Impurity 46 CAS CATO-C4X-252046
| CAS No. | CATO-C4X-252046 |
| Molecular Formula | C18H18Cl2O2 |
| Molecular Weight | 337.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 337.24 g/mol gives Pitolisant Impurity 46 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Pitolisant Impurity 46 (CAS CATO-C4X-252046, C18H18Cl2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, a hydroxyl group, an ether linkage, chlorine substitution, Pitolisant Impurity 46 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 337.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Pitolisant Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18Cl2O2 |
| Molecular Weight | 337.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Pitolisant Standards
- Pitolisant Impurity 1 (CAS CATO-C4X-25201)
- Pitolisant impurity 23 (CAS CATO-C4X-252023)
- Pitolisant impurity 26 (CAS CATO-C4X-252026)
- Pitolisant impurity 29 (CAS CATO-C4X-252029)
- Pitolisant impurity 11 (CAS CATO-C4X-252011)
- Pitolisant impurity 3 (CAS CATO-C4X-25203)
- Pitolisant impurity 37 (CAS CATO-C4X-252037)
- Pitolisant impurity 40 (CAS CATO-C4X-252040)
Recommended Standards
- Vilazodone Impurity 3 (CAS CATO-C4X-13553)
- 3-((4-(Dimethylamino)phenyl)amino)-2-bromo-5,5-dimethylcyclohex-2-en-1-one (CAS 1023865-46-4)
- N-(2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanesulfonamide (CAS 2246751-85-7)
- {4-[4-(4-Amino-2-chlorophenyl)piperazin-1-yl]-3-chlorophenyl}amine (CAS 1174173-34-2)
- Clonazepam impurity 14 (CAS CATO-C4X-140314)
- Sofosbuvir Impurity 87 (CAS 817204-32-3)
- Docetaxel Impurity 42 (CAS 670254-71-4)
- N-(2-Ethylhexyl)-4-(2-thioxo-2,3-dihydro-1H-imidazol-1-yl)benzamide (CAS 111203-86-2)
- 2-Amino-5-oxo-4-(p-tolyl)-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile (CAS 177028-90-9)
- 4-(4-Chloro-1H-pyrazol-1-yl)piperidine hydrochloride (CAS 1443980-02-6)
- 2-Bromo-N,N-dimethyl-4-(5-methylbenzo[d]oxazol-2-yl)aniline (CAS 1706453-76-0)
- 2-(3,5-Diamino-1H-pyrazol-4-yl)-1-phenylethanone (CAS 105576-67-8)
- (R)-1-Boc-amino-butyl-3-amine (CAS 1187927-71-4)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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