Resmetirom Impurity 37 CAS CATO-C4X-291237
| CAS No. | CATO-C4X-291237 |
| Molecular Formula | C12H9Cl2N3O3 |
| Molecular Weight | 314.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Resmetirom Impurity 37 (CAS CATO-C4X-291237), a pharmacopoeial impurity reference standard (molecular formula C12H9Cl2N3O3, MW 314.12 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Resmetirom Impurity 37 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 314.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Resmetirom Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9Cl2N3O3 |
| Molecular Weight | 314.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom Impurity 23 (CAS 2768217-12-3)
- Resmetirom Impurity 6 (CAS 920509-28-0)
- Resmetirom impurity 78 (CAS CATO-C4X-291278)
- Resmetirom impurity 83 (CAS CATO-C4X-291283)
- Resmetirom Impurity 92 (CAS CATO-C4X-291292)
- Resmetirom impurity 93 (CAS CATO-C4X-291293)
- Resmetirom impurity 63 (CAS CATO-C4X-291263)
- Resmetirom impurity 79 (CAS CATO-C4X-291279)
Recommended Standards
- VO5437P1A2 32861-85-1 Chlomethoxyfen [BSI:ISO] Chlormethoxynil Chlomethoxynil 2,4-Dichlorophenyl 3-methoxy-4-nitrophenyl ether Ether, (2,4-dichlorophenyl) (3-methoxy-4-nitrophenyl) X-52 BRN 2158908 CCRIS 7157 Chlomethoxyfen 4-(2,4-Dichlorophenoxy)-2-methoxy-1-nitrobenzene 5-(2,4-Dichlorophenoxy)-2-nitroanisole 2,4-Dichlorophenyl 3'-methoxy-4'-nitrophenyl ether Diphenex EINECS 251-266-1 Ekkusagoni UNII-VO5437P1A2 (CAS 32861-85-1)
- 3-Bromo-4-(2-(cyclopropylamino)-2-oxoethoxy)benzoic acid (CAS 1050911-41-5)
- N-(3,4-Dichlorophenyl)-6-hydroxy-1-methyl-2-oxo-1,2-dihydropyrimidine-4-carboxamide (CAS 861208-54-0)
- N-(4-Bromo-3-(trifluoromethyl)phenyl)hydrazinecarbothioamide (CAS 1303993-77-2)
- Ibuprofen Impurity 67 (CAS CATO-C4X-108267)
- Fluvastatin Impurity 20 (CAS 1025064-18-9)
- Letermovir Impurity 4 (CAS CATO-CP155165)
- O-(4-Phenoxybutyl)hydroxylamine (CAS 54149-55-2)
- Ethyl 3-methoxy-5,6-dihydropyrazine-1(2H)-carboxylate (CAS 190908-89-5)
- 5-Chloro-1-pyridin-2-ylpyrazole-4-carbonitrile (CAS 104771-35-9)
- 1-Propyl-1H-indazole-6-carbaldehyde (CAS 1936487-88-5)
- Finerenone Impurity 167 (CAS CATO-C4X-2880167)
- (5-Bromo-pyridin-3-yl)methanol (CAS 37669-64-0)
- Akt/SKG Substrate Peptide (CAS 276680-69-4)
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