N-Notroso Letermovir impurity 131 CAS CATO-C4X-2915131
| CAS No. | CATO-C4X-2915131 |
| Molecular Formula | C22H21F4N5O4 |
| Molecular Weight | 495.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
N-Notroso Letermovir impurity 131 (CAS CATO-C4X-2915131) is a certified pharmaceutical impurity reference standard with the molecular formula C22H21F4N5O4 and a molecular weight of 495.43 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, N-Notroso Letermovir impurity 131 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 495.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H21F4N5O4 |
| Molecular Weight | 495.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related N Standards
Recommended Standards
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- 7-fluoroquinoxaline-5-carboxylic acid (CAS 1193389-51-3)
- (S)-3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-((1,1,1-trifluoropropan-2-yl)oxy)pyridine (CAS 2281841-15-2)
- 3-(4-Chlorophenyl)-2-methoxypropiophenone (CAS 898787-62-7)
- 4-((6-Fluoro-2-methylquinolin-4-yl)amino)benzoic acid hydrochloride (CAS 1443279-24-0)
- (2R,3S)-5-(2-amino-4-methoxy-1H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol (CAS 86392-74-7)
- Neuropeptide Y, porcine (CAS 82785-45-3)
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