Belumosudil Impurity 16 CAS CATO-C4X-298816
| CAS No. | CATO-C4X-298816 |
| Molecular Formula | C16H11ClN2O2 |
| Molecular Weight | 298.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C16H11ClN2O2, Belumosudil Impurity 16 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 298.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Belumosudil Impurity 16 (CAS CATO-C4X-298816) is a certified pharmaceutical impurity reference standard with the molecular formula C16H11ClN2O2 and a molecular weight of 298.72 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11ClN2O2 |
| Molecular Weight | 298.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Belumosudil Standards
- Belumosudil Impurity 66 (CAS CATO-C4X-298866)
- Belumosudil Impurity 18 (CAS CATO-C4X-298818)
- Belumosudil Impurity 58 (CAS CATO-C4X-298858)
- Belumosudil Impurity 64 (CAS CATO-C4X-298864)
- Belumosudil Impurity 41 (CAS CATO-C4X-298841)
- Belumosudil Impurity 29 (CAS CATO-C4X-298829)
- Belumosudil Impurity 39 (CAS 2121561-39-3)
- Belumosudil Impurity 34 (CAS 1789444-04-7)
Recommended Standards
- Hydrochlorothiazide impurity 48 (CAS CATO-C4X-117748)
- Methotrexate Impurity 77 (CAS CATO-C4X-115477)
- 1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethan-1-one (CAS 1125828-30-9)
- Methotrexate Impurity 70 (CAS CATO-C4X-115470)
- Sildenafil Impurity 271 (CAS 1229017-15-5)
- Lurasidone Impurity 76 (CAS 1318074-27-9)
- Benzylpenicillin impurity 58 (CAS 493-39-0)
- 5-Cyclopropoxy-4-ethyl-N,N-dimethylpyridin-2-amine (CAS 1243402-15-4)
- 4-(4-Aminophenoxy)pyridine (CAS 102877-78-1)
- Mirodenafil (CAS 862189-95-5)
- 3-Difluoromethoxy-6-(trifluoromethyl)pyridine-2-acetic acid (CAS 1227561-57-0)
- tert-butyl (2R)-2-cyanopiperidine-1-carboxylate (CAS 940000-26-0)
- 4-(4-Hydroxy-3-methoxyphenyl)-2-butanone (CAS 122-48-5)
- Insulin Degludec Impurity 24 (CAS CATO-C4X-215724)
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