Lemborexant Impurity 46 CAS CATO-C4X-304246
| CAS No. | CATO-C4X-304246 |
| Molecular Formula | C22H21FN4O2 |
| Molecular Weight | 392.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Lemborexant Impurity 46 (CAS CATO-C4X-304246), a pharmacopoeial impurity reference standard (molecular formula C22H21FN4O2, MW 392.43 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Lemborexant Impurity 46 (C22H21FN4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lemborexant Impurity 46 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21FN4O2 |
| Molecular Weight | 392.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Lemborexant Standards
- Lemborexant Impurity 51 (CAS CATO-C4X-304251)
- Lemborexant impurity 9 (CAS 1369763-94-9)
- Lemborexant impurity 10 (CAS CATO-C4X-304210)
- Lemborexant impurity 11 (CAS CATO-C4X-304211)
- Lemborexant impurity 12 (CAS CATO-C4X-304212)
- Lemborexant impurity 17 (CAS 1450904-92-3)
- Lemborexant Impurity 30 (CAS CATO-C4X-304230)
- Lemborexant Impurity 77 (CAS CATO-C4X-304277)
Recommended Standards
- Relugolix Impurity 35 (CAS CATO-C4X-242935)
- Relugolix Impurity 215 (CAS CATO-C4X-2429215)
- Relugolix Impurity 214 (CAS CATO-C4X-2429214)
- 5-[(2,6-Dimethylphenyl)methyl]-7-(trifluoromethyl)-1H,3H,3aH,4H,5H-[1,3]thiazolo[3,4-a]quinoxalin-4-one (CAS 1025332-07-3)
- Dapagliflozin Impurity 188 (CAS CATO-C4X-1138188)
- Mirabegron Impurity 118 (CAS CATO-C4X-1032118)
- Bifendate Impurity 6 (CAS CATO-C4X-25556)
- 3-(2H-1,3-benzodioxol-5-yl)propan-1-amine (CAS 78498-59-6)
- 2-((3,3,3-Trifluoropropyl)sulfonyl)acetonitrile (CAS 939049-22-6)
- 1,7-Dibromoisoquinolin-3-amine (CAS 925672-86-2)
- 5-Bromo APINACA (CAS 2160555-51-9)
- 6-Amino-9-benzyl-2-(propylthio)-7H-purin-8(9H)-one (CAS 226906-68-9)
- N-(3,4,5-trimethoxybenzyl)pentan-3-amine hydrobromide (CAS 1609404-29-6)
- Semaglutide impurity 75 (CAS CATO-C4X-222675)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com