Ribociclib Impurity 40 CAS CATO-C4X-310040
| CAS No. | CATO-C4X-310040 |
| Molecular Formula | C21H28N8O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 444.97 g/mol gives Ribociclib Impurity 40 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ribociclib Impurity 40 (CAS CATO-C4X-310040, C21H28N8OHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ribociclib Impurity 40 (C21H28N8OHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ribociclib Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H28N8O HCl |
| Molecular Weight | 444.97 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Ribociclib Standards
Recommended Standards
- Piperacillin impurity 98 (CAS CATO-C4X-173298)
- Vazegepant Impurity 19 (CAS 2923756-41-4)
- Alogliptin Impurity 17 (CAS 865758-96-9)
- 5-(2-Chlorophenyl)-1,3-diphenyl-1H-pyrazole (CAS 55042-82-5)
- 2-(4-Cyclohexylphenyl)propanoic acid (CAS 24645-20-3)
- 1,2,3,4-Tetra-O-benzoyl-D-glucopyranose (CAS 590367-95-6)
- 6-(3-Chlorophenyl)pyrimidin-4-amine (CAS 1192814-53-1)
- (5-Chloro-2-methylphenyl)methanol (CAS 58966-29-3)
- 1H-pyrazole-3,5-dicarbonitrile (CAS 847573-68-6)
- Semaglutide impurity 103 (CAS 1446013-07-5)
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