Zeteletinib Impurity 1 CAS CATO-C4X-32161
| CAS No. | CATO-C4X-32161 |
| Molecular Formula | C23H16ClN5O2 |
| Molecular Weight | 429.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Zeteletinib Impurity 1 (CAS CATO-C4X-32161, C23H16ClN5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Zeteletinib Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 429.86 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C23H16ClN5O2 |
| Molecular Weight | 429.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Zeteletinib Standards
Recommended Standards
- N-{[(4-chlorophenyl)carbamoyl]amino}-2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetamide (CAS 251310-54-0)
- 1-(2-Chloro-5-fluorobenzoyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775304-87-4)
- N-(2-Chlorophenyl)-2-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-1,3-dioxo-1H,2H,3H,5H,6H,7H,8H-pyrido[1,2-c]pyrimidin-2-yl]acetamide (CAS 1775554-16-9)
- 1-(2-Chloro-4-fluorobenzoyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775482-26-2)
- Netupitant Impurity 3 (CAS CATO-C4X-12233)
- Budesonide EP Impurity F(Desonide) (CAS 638-94-8)
- Canagliflozin Impurity 40 (CAS 1030825-20-7)
- Ethyl 5-chlorobenzo[b]thiophene-2-carboxylate (CAS 13771-67-0)
- 2-[(benzylcarbamoyl)amino]-3-methylbutanoic acid (CAS 1009681-22-4)
- 2-(1-Methyl-1H-pyrazol-4-yl)cyclohexanone (CAS 1250151-55-3)
- 2-Methyl-1-benzothiophen-7-ol (CAS 197803-66-0)
- Baceridin (CAS 1622872-91-6)
- Acid-PEG2-SS-PEG2-acid (CAS 1807539-10-1)
- Semaglutide Impurity 15 (CAS CATO-C4X-222615)
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