Enarodustat Impurity 8 CAS CATO-C4X-32288
| CAS No. | CATO-C4X-32288 |
| Molecular Formula | C10H11ClN4O2 |
| Molecular Weight | 254.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Enarodustat Impurity 8 (CAS CATO-C4X-32288, C10H11ClN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Enarodustat Impurity 8 (C10H11ClN4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 254.67 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C10H11ClN4O2 |
| Molecular Weight | 254.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 0.95 |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Enarodustat Standards
- Enarodustat Impurity 1 (CAS CATO-C4X-32281)
- Enarodustat Impurity 16 (CAS CATO-C4X-322816)
- Enarodustat Impurity 18 (CAS CATO-C4X-322818)
- Enarodustat Impurity 14 (CAS CATO-C4X-322814)
- Enarodustat Impurity 21 (CAS CATO-C4X-322821)
- Enarodustat Impurity 27 (CAS CATO-C4X-322827)
- Enarodustat Impurity 6 (CAS CATO-C4X-32286)
- Enarodustat Impurity 3 (CAS CATO-C4X-32283)
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- 5-Chloro-1,2,3-thiadiazole-4-carbaldehyde (CAS 100305-91-7)
- 1-(4-Chlorophenyl)-5-(3-nitrophenyl)-1h-imidazole-2-thiol (CAS 1105189-21-6)
- 5-(4-Fluorophenyl)-3-methyl-2-sulfanyl-3h,4h-thieno[2,3-d]pyrimidin-4-one (CAS 436090-38-9)
- 2-(Trifluoromethyl)-1h-1,3-benzodiazol-6-amine hydrochloride (CAS 1185303-39-2)
- 3-((3-(Dodecyloxy)propyl)amino)butanoic acid (CAS 6582-30-5)
- Gastric Inhibitory Polypeptide (1-30) amide (porcine) (CAS 134846-93-8)
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