Orforglipron impurity 76 CAS CATO-C4X-323476
| CAS No. | CATO-C4X-323476 |
| Molecular Formula | C28H31N3O2 |
| Molecular Weight | 441.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Orforglipron impurity 76 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Orforglipron impurity 76 (CAS CATO-C4X-323476), a pharmacopoeial impurity reference standard (molecular formula C28H31N3O2, MW 441.56 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Orforglipron impurity 76 (C28H31N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 441.56 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Orforglipron impurity 76 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H31N3O2 |
| Molecular Weight | 441.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Orforglipron Standards
- Orforglipron Impurity 12 (CAS 2212021-81-1)
- Orforglipron impurity 123 (CAS CATO-C4X-3234123)
- Orforglipron impurity 124 (CAS CATO-C4X-3234124)
- Orforglipron impurity 69 (CAS CATO-C4X-323469)
- Orforglipron impurity 75 (CAS CATO-C4X-323475)
- Orforglipron impurity 77 (CAS CATO-C4X-323477)
- Orforglipron impurity 99 (CAS CATO-C4X-323499)
- Orforglipron Impurity 13 (CAS 2212021-61-7)
Recommended Standards
- N-(4-(Benzo[d]thiazol-2-yl)phenyl)-3-(quinolin-2-ylthio)propanamide (CAS 671198-70-2)
- N-(3-(5,6-diethyl-4-oxo-1,4-dihydropyrimidin-2-yl)-4-propoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide (CAS 1229018-87-4)
- HX 630 (CAS 188844-52-2)
- Etoricoxib Impurity 12 (CAS CATO-C4X-108012)
- Loratadine Impurity 95 (CAS CATO-C4X-142695)
- Cenobamate Impurity 63 (CAS CATO-C4X-241663)
- Butenafine Impurity 2 (CAS 19692-45-6)
- 1-(4-Nitrophenyl)-4-(5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 1294374-23-4)
- POTASSIUM CYANIDE (CAS 151-50-8)
- 6-Hydroxy-2-(propan-2-ylidene)-7-propylbenzofuran-3(2H)-one (CAS 88281-15-6)
- 2-Chloro-5-(chlorosulfonyl)-benzoyl chloride (CAS 547739-66-2)
- 1-Nitro-4-((phenylsulfonyl)methyl)benzene (CAS 34063-53-1)
- 4-Chloro-2,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidine (CAS 78756-80-6)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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