Iptacopan Impurity 8 CAS CATO-C4X-32648
| CAS No. | CATO-C4X-32648 |
| Molecular Formula | C46H50N4O7 |
| Molecular Weight | 770.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Iptacopan Impurity 8.
Iptacopan Impurity 8 (CAS CATO-C4X-32648) is a certified pharmaceutical impurity reference standard with the molecular formula C46H50N4O7 and a molecular weight of 770.91 g/mol.
Structurally, Iptacopan Impurity 8 (C46H50N4O7) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 24.0, corresponding to approximately 24 ring(s) or double-bond equivalent(s). With a molecular weight of 770.91 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C46H50N4O7 |
| Molecular Weight | 770.91 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
Related Iptacopan Standards
- Iptacopan Impurity 10 (CAS CATO-C4X-326410)
- Iptacopan Impurity 9 (CAS CATO-C4X-32649)
- Iptacopan Impurity 7 (CAS 1644670-76-7)
- Iptacopan (CAS 1644670-37-0)
- Iptacopan Impurity 6 (CAS CATO-C4X-32646)
- Iptacopan Impurity 4 (CAS 1644667-61-7)
- Iptacopan Impurity 3 (CAS 1387445-50-2)
- Iptacopan Impurity 5 (CAS 3040999-15-0)
Recommended Standards
- N2,N2,N2',N2'-Tetrakis(4-methoxyphenyl)-9,9'-spirobi[fluorene]-2,2'-diamine (CAS 1174006-40-6)
- Bisbentiamine (CAS 2667-89-2)
- 2,7-Bis[N,N-bis(4-methoxyphenyl)amino]-9,9-spirobi[9H-fluorene] (CAS 1138220-69-5)
- 1,4-Phenylene bis(4-((9-(acryloyloxy)-3-methylnonyl)oxy)benzoate) (CAS 123864-17-5)
- Roxadustat Impurity 172 (CAS CATO-C4X-2213172)
- Etofenamate Impurity 13 (CAS CATO-C4X-260313)
- Venetoclax Impurity 27 (CAS CATO-C4X-249527)
- (S)-1-(3-fluoro-4-methylphenyl)butan-1-amine (CAS 321840-48-6)
- N-((4-Chlorobutanoyl)oxy)-2-(quinolin-8-yloxy)acetimidamide (CAS 88758-08-1)
- 3-[4-(chloromethyl)phenoxy]oxolane (CAS 126049-18-1)
- 5-(2-Formylcyclohex-1-en-1-yl)nicotinonitrile (CAS 1502825-46-8)
- rel-(2R,4S)-tert-Butyl 4-hydroxy-2-(trifluoromethyl)piperidine-1-carboxylate (CAS 1445804-81-8)
- Fumonisin Mix 3 (B1,B2,B3) (CAS CATO-LCFD201133-AL)
- Exenatide Acetate (CAS 141732-76-5)
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