Clonixin Impurity 2 CAS CATO-C4X-33852
| CAS No. | CATO-C4X-33852 |
| Molecular Formula | C13H11ClN2O2 |
| Molecular Weight | 262.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clonixin Impurity 2.
As a process- or degradation-related impurity, Clonixin Impurity 2 (CAS CATO-C4X-33852, C13H11ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clonixin Impurity 2 (C13H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 262.69 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11ClN2O2 |
| Molecular Weight | 262.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clonixin Standards
Recommended Standards
- Momelotinib impurity 12 (CAS 97604-14-3)
- 4'-Chloro-1,1''-dimethyl-1h,1'h,1''h-4,3':5',4''-terpyrazole (CAS 1240119-13-4)
- Finerenone Impurity 24 (CAS CATO-C4X-288024)
- 5-amino-1-(3-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-2-yl)-1H-pyrazole-4-carbonitrile (CAS 149978-57-4)
- Lansoprazole EP Impurity A (CAS 213476-12-1)
- Encorafenib Impurity 2 (CAS 1269440-29-0)
- Tretinoin Impurity 12 (CAS 3899-20-5)
- Metoprolol Impurity 33 (CAS CATO-C4X-136733)
- Patiromer - API Standards (CAS 1260643-52-4)
- 5-Amino-2-bromo-4-fluorobenzoic Acid Methyl Ester (CAS 1036389-86-2)
- (1Z)-2-(1H-benzimidazol-2-yl)-1-thien-2-ylethanone oxime (CAS 924860-60-6)
- 2-(2,2,2-Trifluoroethoxy)isoindoline-1,3-dione (CAS 76029-67-9)
- 5-Phenyl-3-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one (CAS 59591-39-8)
- Atrial Natriuretic Peptide (ANP)(1-28) Alpha (Human, Ovine, Canine) (CAS 91917-63-4)
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