Trabectedin Impurity 1 CAS CATO-C4X-35651
| CAS No. | CATO-C4X-35651 |
| Molecular Formula | C39H43N3O12S |
| Molecular Weight | 777.84 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Trabectedin Impurity 1 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Trabectedin Impurity 1 (CAS CATO-C4X-35651, C39H43N3O12S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Trabectedin Impurity 1 (C39H43N3O12S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 777.84 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C39H43N3O12S |
| Molecular Weight | 777.84 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Trabectedin Standards
Recommended Standards
- 5-Bromo-2,9-di(undecan-6-yl)anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone (CAS 1309387-42-5)
- Levothyroxine Impurity 20 (CAS 7069-47-8)
- N-Nitroso Amoxicillin Impurity K (CAS CATO-C4X-114880)
- Docetaxel Impurity 54 (CAS 173101-47-8)
- Lacosamide EP Impurity I(R-Isomer) (CAS 2295925-90-3)
- Atogepant Impurity 71 (CAS CATO-C4X-328571)
- Etomidate Impurity 16 (CAS CATO-C4X-188416)
- (2,6-Dimethylmorpholino)(3-methylbenzofuran-2-yl)methanone (CAS 588674-74-2)
- Clofazimine (CAS 2030-63-9)
- 5-Hydroxy-4'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261916-43-1)
- 4-Methyl-2-(piperidin-4-yloxy)pyridine dihydrochloride (CAS 944390-73-2)
- 1-(3-Chloro-2-methoxyphenyl)ethanone (CAS 99585-09-8)
- 2-Hydroxy-4-(trifluoromethyl)-7,8-dihydroquinazolin-6(5H)-one (CAS 1233026-77-1)
- Semaglutide Impurity 164 (CAS CATO-C4X-2226164)
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