Valsartan Impurity 121 CAS 1000986-63-9
| CAS No. | 1000986-63-9 |
| Molecular Formula | C39H37N5O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Valsartan Impurity 121 (CAS 1000986-63-9, C39H37N5O2C2H2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Valsartan Impurity 121 (C39H37N5O2C2H2O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 25.0, corresponding to approximately 25 ring(s) or double-bond equivalent(s). With a molecular weight of 697.79 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Valsartan Impurity 121 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C39H37N5O2 C2H2O4 |
| Molecular Weight | 697.79 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 25.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 5 |
Related Valsartan Standards
- (S)-(-)-Valsartan-d8 (valine-d8) (CAS 1089736-72-0)
- Valsartan-d9 (Major) (CAS 1089736-73-1)
- Valsartan Impurity 13 ( Valproic Acid EP Impurity A ) (CAS 109-52-4)
- Valsartan Impurity 35 HCl (CAS 1111177-20-8)
- Valsartan Impurity 9 (CAS 1111177-30-0)
- Valsartan Impurity 10 (CAS 114772-54-2)
- Valsartan Impurity 82 (CAS 1189547-11-2)
- Valsartan Isopropyl Ester (CAS 1245820-09-0)
Recommended Standards
- Miconazole EP Impurity I (CAS 47363-37-1)
- Atrasentan Impurity 172 (CAS 1059051-96-5)
- Ketoprofen EP Impurity F (CAS 42872-30-0)
- 4-Fluoro-2-methyl-N-(2-(thiophen-3-yl)ethyl)benzenesulfonamide (CAS 1060261-76-8)
- (2Z)-2-[(6-Methyl-1,2,3,4-tetrahydroquinolin-1-yl)methylidene]-3-oxo-N-phenylbutanamide (CAS 1024791-93-2)
- 2-(1-benzofuran-2-yl)-1,3-thiazole-4-carboxylic acid (CAS 1152604-97-1)
- N-(2,3-Dichlorophenyl)-2-fluorobenzamide (CAS 200710-81-2)
- 2-(N-Boc-amino)thiophene (CAS 56267-50-6)
- (S)-1-(4-BROMOPYRIDIN-2-YL)-2,2,2-TRIFLUOROETHAN-1-AMINE (CAS 1213859-26-7)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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