Ethyl 4-chloro-2-methylquinoline-6-carboxylate CAS 100375-87-9
| CAS No. | 100375-87-9 |
| Molecular Formula | C13H12ClNO2 |
| Molecular Weight | 249.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 4-chloro-2-methylquinoline-6-carboxylate (C13H12ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Ethyl 4-chloro-2-methylquinoline-6-carboxylate (CAS 100375-87-9), molecular formula C13H12ClNO2 and molecular weight 249.69 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 4-chloro-2-methylquinoline-6-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12ClNO2 |
| Molecular Weight | 249.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- 1-(2-Chloro-6-ethoxyquinolin-3-yl)ethanone (CAS 1017429-04-7)
- 2-Chloro-6-(4-methoxybenzyloxy)pyridine (CAS 1020253-23-9)
- 3-Chloro-2-(4-methoxybenzyloxy)pyridine (CAS 1033202-56-0)
- 6-Chloro-1-(cyclopropanecarbonyl)-2,3-dihydroquinolin-4(1H)-one (CAS 103604-80-4)
- Methyl 4-chloro-7,8-dimethylquinoline-2-carboxylate (CAS 1133115-70-4)
- 6-Chloro-8-methyl-1-(2-oxopropyl)quinolin-4(1H)-one (CAS 1208825-90-4)
- 8-Chloro-2-methyl-1-(2-oxopropyl)quinolin-4(1H)-one (CAS 1209953-32-1)
- 4-Chloro-2-((2-methoxybenzyl)oxy)pyridine (CAS 1346707-12-7)
Recommended Standards
- Clothianidin (CAS 210880-92-5)
- Thiamethoxam Impurity 1 (CAS 131748-59-9)
- Diazoxide Impurity 2 (CAS 54981-41-8)
- 3-(5-(4-Methylphenyl)-1,3-oxazol-2-yl)propanoyl chloride (CAS 1023817-07-3)
- 4-(Allyloxy)aniline (CAS 1688-69-3)
- 3-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]piperidine (CAS 1864060-59-2)
- 2-Chloro-5-(difluoromethyl)-3-iodo-6-(trifluoromethyl)pyridine (CAS 1804496-63-6)
- Bis(2,4-dichloro-5-nitrophenyl) carbonate (CAS 39489-75-3)
- 4-(3-Chloro-5-fluorophenyl)phenylacetic acid (CAS 1334499-97-6)
- Methyl 1-Methyl-1H-benzo[d]imidazole-2-carboxylate (CAS 2849-92-5)
- (3-Methyl-1,2,4-oxadiazol-5-yl)(phenyl)methanol (CAS 1341828-39-4)
- Empagliflozin impurity 258 (CAS CATO-C4X-1065258)
- 5-(Bromomethyl)-2-pyrazinecarboxylic acid (CAS 782434-80-4)
- Semaglutide Impurity 164 (CAS CATO-C4X-2226164)
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