Risperidone Impurity 27 CAS 1005191-81-0
| CAS No. | 1005191-81-0 |
| Molecular Formula | C23H27FN4O2 |
| Molecular Weight | 410.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Risperidone Impurity 27 (CAS 1005191-81-0, C23H27FN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Risperidone Impurity 27 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 410.48 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H27FN4O2 |
| Molecular Weight | 410.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Risperidone Standards
- Risperidone EP Impurity D (CAS 1199589-74-6)
- Risperidone Impurity 42 (CAS CATO-C4X-111142)
- Risperidone Impurity (CAS CATO-C4X-111144)
- Risperidone Impurity (CAS CATO-C4X-111145)
- Risperidone (CAS 106266-06-2)
- Risperidone impurity 46 (CAS 106266-11-9)
- Risperidone USP Related Compound G (CAS 152542-00-2)
- Risperidone-d4 (CAS 1020719-76-9)
Recommended Standards
- tert-Butyl 3-((1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)amino)pyrrolidine-1-carboxylate (CAS 885270-87-1)
- tert-butyl (4S)-4-(tert-butoxycarbonylamino)-3-fluoro-spiro[4,6-dihydropyrrolo[1,2-b]pyrazole-5,4'-piperidine]-1'-carboxylate (CAS 2843690-98-0)
- 5-(2-(Diethylamino)ethyl)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-3-methyl-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one (CAS 945380-27-8)
- Roxadustat Impurity 54 (CAS CATO-C4X-221354)
- Iohexol EP Impurity F HCl (2,4-diiodo Isomer) (CAS CATO-CP107405)
- Sunitinib Impurity 27 (CAS 1104253-05-5)
- Ilaprazole Impurity 85 (CAS CATO-C4X-113085)
- 6-(Cyclohexyloxy)pyrimidine-2,4,5-triamine hydrochloride (CAS 2135613-82-8)
- 3-[4-(aminocarbonyl)phenyl]acrylic acid (CAS 18910-25-3)
- Methyl 4-(4-hydroxyisoquinoline-1-carbonyl)benzoate (CAS 1374249-68-9)
- (4-(4-Methylpiperidin-1-yl)-2-(trifluoromethyl)phenyl)boronic acid (CAS 2225169-20-8)
- [1-(aminomethyl)-3,3-dimethylcyclobutyl]methanol (CAS 1489162-37-9)
- Mupirocin EP Impurity C (CAS 85248-93-7)
- Liraglutide Impurity 20 TFA Salt (CAS CATO-C4X-199220)
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