Methylnaltrexone Bromide Impurity 4 CAS 1005410-32-1
| CAS No. | 1005410-32-1 |
| Molecular Formula | C21H26NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methylnaltrexone Bromide Impurity 4 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methylnaltrexone Bromide Impurity 4 (CAS 1005410-32-1) is a certified pharmaceutical impurity reference standard with the molecular formula C21H26NO4Br and a molecular weight of 436.35 g/mol.
Structurally, Methylnaltrexone Bromide Impurity 4 (C21H26NO4Br) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 436.35 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Methylnaltrexone Bromide Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H26NO4 Br |
| Molecular Weight | 436.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Methylnaltrexone Standards
- Methylnaltrexone Bromide Impurity 1 (CAS 1027638-96-5)
- Methylnaltrexone Bromide - API Standards (CAS 916055-92-0)
- Methylnaltrexone (CAS 916055-93-1)
- Methylnaltrexone Bromide Impurity 25 (CAS CATO-C4X-147525)
- Methylnaltrexone Bromide Impurity 10 (CAS CATO-C4X-152110)
- Methylnaltrexone Bromide Impurity 11 (CAS CATO-C4X-152111)
- Methylnaltrexone Bromide Impurity 12 (CAS CATO-C4X-152112)
- Methylnaltrexone Bromide Impurity 13 (CAS CATO-C4X-152113)
Recommended Standards
- Mianserin Impurity 121 (CAS CATO-C4X-1369121)
- Arbidol Impurity 38 (CAS CATO-C4X-112938)
- Cefcapene Impurity 104 (CAS CATO-C4X-1824104)
- 5-(N,N-dimethylsulfamoyl)-2-methoxybenzoic acid (CAS 93798-20-0)
- 1-Methyl-3-nitro-1H-pyrazole-4-carboxamide (CAS 39205-70-4)
- 2-Bromo-4-chloro-6-fluorobenzenesulfonamide (CAS 1204573-10-3)
- (1R,2R)-1-(Diphenylphosphino)-1-phenylpropan-2-amine (CAS 799297-44-2)
- 4-Methyl-3-(methylsulfonyl)benzonitrile (CAS 1161921-91-0)
- 2,2-Dibromo-1-(2-methoxyphenyl)ethan-1-one (CAS 1121543-12-1)
- Semaglutide (CAS 910463-68-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com