Methylnaltrexone Bromide Impurity 1 CAS 1027638-96-5
| CAS No. | 1027638-96-5 |
| Molecular Formula | C21H24NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Methylnaltrexone Bromide Impurity 1 (CAS 1027638-96-5, C21H24NO4Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Methylnaltrexone Bromide Impurity 1 (C21H24NO4Br) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H24NO4 Br |
| Molecular Weight | 434.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Methylnaltrexone Standards
- Methylnaltrexone Bromide Impurity 4 (CAS 1005410-32-1)
- Methylnaltrexone Bromide - API Standards (CAS 916055-92-0)
- Methylnaltrexone (CAS 916055-93-1)
- Methylnaltrexone Bromide Impurity 25 (CAS CATO-C4X-147525)
- Methylnaltrexone Bromide Impurity 10 (CAS CATO-C4X-152110)
- Methylnaltrexone Bromide Impurity 11 (CAS CATO-C4X-152111)
- Methylnaltrexone Bromide Impurity 12 (CAS CATO-C4X-152112)
- Methylnaltrexone Bromide Impurity 13 (CAS CATO-C4X-152113)
Recommended Standards
- Sulpiride EP Impurity B (CAS 33045-52-2)
- Gadoteridol Impurity 51 (CAS CATO-C4X-225751)
- Elagolix Impurity 115 (CAS CATO-C4X-2068115)
- 2-(Sulfooxy)acetic acid (CAS 3233-46-3)
- 4,7-Dihydroxy-2-oxo-2H-chromene-3-carbaldehyde (CAS 51069-94-4)
- Methyl 6-(4-nitrophenoxy)pyridazine-3-carboxylate (CAS 1354961-27-5)
- D-Ribose-2,3,4,5- (CAS 478506-23-9)
- p-Hydroxyrecainam (CAS 130996-41-7)
- 4-(4-Methoxyphenoxy)tetrahydro-2H-pyran-4-carboxylic acid (CAS 1308645-48-8)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com