Pyridoxine EP Impurity A hydrochloride CAS 1006-21-9
| CAS No. | 1006-21-9 |
| Molecular Formula | C8H9NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pyridoxine EP Impurity A hydrochloride.
As a process- or degradation-related impurity, Pyridoxine EP Impurity A hydrochloride (CAS 1006-21-9, C8H9NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Pyridoxine EP Impurity A hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 187.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9NO2 HCl |
| Molecular Weight | 187.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pyridoxine Standards
- Pyridoxine /Vitamin B6 Impurity 63 HCl (CAS 102694-13-3(free base))
- Pyridoxine dicaprylate (CAS 106483-04-9)
- Pyridoxine N-Oxide HCl (CAS 112507-12-7)
- Pyridoxine Impurity 27 (CAS 116169-14-3)
- Pyridoxine-d3 Hydrochloride (CAS 1189921-12-7)
- Pyridoxine Impurity 6 (CAS 1385767-85-0)
- Pyridoxine Impurity 7 (CAS 1385767-86-1)
- Pyridoxine EP Impurity B Hydrochloride (CAS 148-51-6)
Recommended Standards
- Cycloserine Impurity 9 (CAS 31697-35-5)
- Canagliflozin Impurity 111 (CAS CATO-C4X-1123111)
- Elagolix Impurity 80 (CAS CATO-C4X-206880)
- 4-Amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinaldehyde (CAS 1351276-65-7)
- Mirabegron Impurity 6 (CAS 1684452-83-2)
- 6-Methyl-5-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (CAS 2529570-32-7)
- 2-(4-Oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl)acetic acid (CAS 17547-79-4)
- 2-((4,6-Dimethylpyrimidin-2-yl)thio)-N-methylethan-1-amine (CAS 1249592-49-1)
- (S)-1-(2,4-difluorophenyl)-2-methylpropan-1-amine (CAS 1213059-66-5)
- Tirzepatide Impurity 24 X TFA Salt (CAS CATO-C4X-324024)
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