Pyridoxine EP Impurity B Hydrochloride CAS 148-51-6
| CAS No. | 148-51-6 |
| Molecular Formula | C8H11NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Pyridoxine EP Impurity B Hydrochloride.
CATO supplies Pyridoxine EP Impurity B Hydrochloride (CAS 148-51-6), a pharmacopoeial impurity reference standard (molecular formula C8H11NO2HCl, MW 189.64 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Pyridoxine EP Impurity B Hydrochloride (C8H11NO2HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Pyridoxine EP Impurity B Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H11NO2 HCl |
| Molecular Weight | 189.64 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Pyridoxine Standards
- Pyridoxine EP Impurity A hydrochloride (CAS 1006-21-9)
- Pyridoxine /Vitamin B6 Impurity 63 HCl (CAS 102694-13-3(free base))
- Pyridoxine dicaprylate (CAS 106483-04-9)
- Pyridoxine N-Oxide HCl (CAS 112507-12-7)
- Pyridoxine Impurity 27 (CAS 116169-14-3)
- Pyridoxine-d3 Hydrochloride (CAS 1189921-12-7)
- Pyridoxine Impurity 6 (CAS 1385767-85-0)
- Pyridoxine Impurity 7 (CAS 1385767-86-1)
Recommended Standards
- Teprenone Impurity 1 (CAS 158734-06-6)
- Magnesium Pidolate EP Impurity B (CAS 29227-92-7)
- Bexagliflozin Impurity 10 (CAS CATO-C4X-332210)
- (S)-5'-Bromo-2',3'-dihydrospiro[imidazolidine-4,1'-indene]-2,5-dione (CAS 1889290-53-2)
- 2,2,2-Trifluoro-1-(2,4,6-trifluorophenyl)ethan-1-ol (CAS 1305917-51-4)
- 8,10-dimethoxy-1,1,10b-trimethyl-5H-oxazolo[4,3-a]phthalazine-3,6-dione (CAS 728025-45-4)
- 3-Methyl-2-(pyridin-4-yl)-2,3-dihydroquinazolin-4(1H)-one (CAS 1245570-10-8)
- 6-bromo-3-(4-bromophenyl)-3,4-dihydroquinazoline (CAS 65331-45-5)
- 16b-Hydroxyfurazabol (CAS 36455-74-0)
- Tirzepatide Impurity 16 (CAS CATO-C4X-324016)
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