1-[4-(1,5-dimethyl-1h-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxylic acid CAS 1006348-78-2
| CAS No. | 1006348-78-2 |
| Molecular Formula | C16H18F3N5O2 |
| Molecular Weight | 369.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
1-[4-(1,5-dimethyl-1h-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxylic acid (CAS 1006348-78-2), molecular formula C16H18F3N5O2 and molecular weight 369.34 g/mol, is a CATO reference standard with documented purity and traceability.
1-[4-(1,5-dimethyl-1h-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl]piperidine-3-carboxylic acid (C16H18F3N5O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18F3N5O2 |
| Molecular Weight | 369.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related dimethyl Standards
- 1-(4-(1,3-Dimethyl-1H-pyrazol-4-yl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidine-4-carboxylic acid (CAS 1006334-19-5)
- N'-(4,6-dimethyl-3-(methylsulfonyl)pyridin-2-yl)-2,6-difluoro-N'-methylbenzohydrazide (CAS 341967-39-3)
- 1-(2-(2,2-Dimethyl(3-oxaindan-4-yloxy))acetyl)-4-(2-methylphenyl)semicarbazide (CAS 1022319-72-7)
- 2-(2,5-Dimethyl-1H-indol-3-yl)-1-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)ethanone (CAS 1197769-65-5)
- N-(1-(5,6-dimethyl-1H-benzo[d]imidazol-2-yl)-2-phenylethyl)benzamide (CAS 338410-51-8)
- Dimethyl 6,6'-bis(chloromethyl)-[2,2'-bipyridine]-4,4'-dicarboxylate (CAS 1956377-23-3)
- Dimethyl 5-(4-chlorophenyl)-4,6-dioxotetrahydro-2H-pyrrolo[3,4-d]isoxazole-3,3(3aH)-dicarboxylate (CAS 338420-26-1)
- 3,3-Dimethyl-11-(2-naphthyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (CAS 886644-59-3)
Recommended Standards
- 6,6''-Di(2H-tetrazol-5-yl)-2,2':6',2''-terpyridine (CAS 1030597-82-0)
- 873110-62-4 2-(4-Nitrophenyl)-1H-anthra[1,2-d]imidazole-6,11-dione MFCD20265335 (CAS 873110-62-4)
- RU58841 (CAS 154992-24-2)
- N-(3,4-Dimethoxyphenyl)-3-nitro-4-(1H-1,2,4-triazol-1-yl)benzamide (CAS 338407-92-4)
- 3-Chloroimidazo[1,2-b]pyridazin-6-amine (CAS 1823338-74-4)
- 1-(2-bromoethyl)-1H-pyrazole hydrobromide (CAS 1955531-53-9)
- N-(4-(5-Chlorobenzo[d]oxazol-2-yl)phenyl)-3-nitrobenzamide (CAS 331668-02-1)
- 3-Cyclopropoxy-2-(methylthio)benzonitrile (CAS 1243441-58-8)
- Carmustine EP Impurity B (CAS 689-98-5)
- (6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetic acid hydrochloride (CAS 1187929-27-6)
- Pretomanid-4d (CAS 1346617-34-2)
- Ibudilast (CAS 50847-11-5)
- 5-Cyclopropoxy-N,N-dimethyl-6-nitropyridin-3-amine (CAS 1243457-10-4)
- Gastrin Tetrapeptide (CAS 1947-37-1)
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