4-(1H-1,2,4-triazol-1-yl)-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-5-ol CAS 1007029-49-3
| CAS No. | 1007029-49-3 |
| Molecular Formula | C12H8F3N5O2 |
| Molecular Weight | 311.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-(1H-1,2,4-triazol-1-yl)-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-5-ol is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-(1H-1,2,4-triazol-1-yl)-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-5-ol (CAS 1007029-49-3), a certified reference material (molecular formula C12H8F3N5O2, MW 311.22 g/mol) for analytical method development and quality control.
The molecular framework of 4-(1H-1,2,4-triazol-1-yl)-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-5-ol (C12H8F3N5O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(1H-1,2,4-triazol-1-yl)-1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-5-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8F3N5O2 |
| Molecular Weight | 311.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related H Standards
- 13-[4-(1H-1,2,4-Triazol-1-yl)phenyl]-1,8,10-triazatricyclo[7.4.0.0^{2,7}]trideca-2,4,6,8,10,12-hexaene (CAS 685109-14-2)
- (4-(1H-1,2,3-Triazol-1-yl)piperidin-1-yl)(adamantan-1-yl)methanone (CAS 1795361-06-6)
- 2-(4-(1H-1,2,4-triazol-5-yl)-1H-pyrazol-1-yl)-3-chloro-5-(trifluoromethyl)pyridine (CAS 321526-20-9)
- 2-(4-(1H-1,2,4-triazol-1-yl)phenyl)-2-((2-fluoro-5-methylphenyl)amino)acetonitrile (CAS 866157-63-3)
- 2-((4-((1H-1,2,4-triazol-1-yl)methyl)phenyl)amino)-4-methylthiazole-5-carboxylic acid (CAS 1189749-61-8)
- 2-(2-((4-((1H-1,2,4-Triazol-1-yl)methyl)phenyl)amino)thiazol-4-yl)acetic acid (CAS 1630861-11-8)
- 1-(3-(1H-1,2,3-Triazol-1-yl)azetidin-1-yl)-3-(naphthalen-1-yl)propan-1-one (CAS 2034522-55-7)
- 3-((1H-1,2,4-Triazol-5-yl)thio)-1-(3,5-dimethylphenyl)pyrrolidine-2,5-dione (CAS 364624-08-8)
Recommended Standards
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