Methylprednisolone Impurity 72 CAS 1012306-79-4
| CAS No. | 1012306-79-4 |
| Molecular Formula | C22H27IO4 |
| Molecular Weight | 482.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Methylprednisolone Impurity 72 (CAS 1012306-79-4) is a certified pharmaceutical impurity reference standard with the molecular formula C22H27IO4 and a molecular weight of 482.35 g/mol.
Based on its molecular formula C22H27IO4, Methylprednisolone Impurity 72 contains a flavonoid core, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 482.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Methylprednisolone Impurity 72 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H27IO4 |
| Molecular Weight | 482.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | I-containing |
Related Methylprednisolone Standards
- Methylprednisolone Impurity 51 (CAS CATO-C4X-191951)
- Methylprednisolone Impurity 77 (CAS CATO-C4X-191977)
- Methylprednisolone Hydrogen Succinate EP Impurity D (CAS 119657-85-1)
- MethylPrednisolone Impurity 66 (CAS CATO-C4X-191966)
- Methylprednisolone Impurity 76 (CAS CATO-C4X-191976)
- Methylprednisolone impurity 88 (CAS CATO-C4X-191988)
- Methylprednisolone Impurity 52 (CAS CATO-C4X-191952)
- Methylprednisolone Hydrogen Succinate EP Impurity F (CAS 2376134-25-5)
Recommended Standards
- Mometasone Impurity 49 (CAS CATO-C4X-170449)
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- Tris(2,5-dioxopyrrolidin-1-yl) 2,2',2''-nitrilotriacetate (CAS 401514-72-5)
- Adefovir Impurity 30 (CAS 365417-53-4)
- Triamcinolone Acetonide Impurity 49 (CAS 7704-77-0)
- FrovatriptanImpurity 75 (CAS 158930-18-8（free base）)
- hirsutine (CAS 7729-23-9)
- 5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide (CAS 148472-83-7)
- N-(2,5-Dichlorophenyl)-2-(methylthio)nicotinamide (CAS 1012525-61-9)
- Benzyl 2,3,4-Tri-O-benzyl-D-glucuronate (CAS 53684-90-5)
- 3-Methoxy-2-methylbenzamide (CAS 135329-22-5)
- Rivaroxaban Impurity 60 (CAS CATO-C4X-109060)
- Semaglutide Impurity 7 (CAS CATO-C4X-22267)
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