Adefovir Impurity 30 CAS 365417-53-4
| CAS No. | 365417-53-4 |
| Molecular Formula | C18H28N5O10P |
| Molecular Weight | 505.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Adefovir Impurity 30 (CAS 365417-53-4, C18H28N5O10P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Adefovir Impurity 30 (C18H28N5O10P) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H28N5O10P |
| Molecular Weight | 505.42 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 5 |
Related Adefovir Standards
- Adefovir Dipivoxil (CAS 142340-99-6)
- Adefovir Impurity 28 (CAS CATO-C4X-115228)
- Adefovir impurity 38 (CAS CATO-C4X-115238)
- Adefovir Impurity 8 (CAS 1416439-02-5)
- Adefovir Impurity 15 (CAS CATO-C4X-115215)
- Adefovir Impurity 7 (CAS 1215101-40-8)
- Adefovir Impurity 29 (CAS CATO-C4X-115229)
- Adefovir impurity 11 (CAS CATO-C4X-115211)
Recommended Standards
- 2,5-Dichloro-N-(9-styrylacridin-2-yl)benzenesulfonamide (CAS 88522-60-5)
- Dolutegravir Impurity 66 (CAS CATO-C4X-162066)
- 1-(2-{7-[5-(2,4-dichlorophenyl)furan-2-yl]pyrazolo[1,5-a]pyrimidin-2-yl}thiophen-3-yl)-2,5-dimethyl-1H-pyrrole (CAS 861209-76-9)
- Upadacitinib Impurity 193 (CAS CATO-C4X-2405193)
- Dopamine Impurity 73 (CAS CATO-C4X-190873)
- Bimatoprost Impurity 23 (CAS CATO-C4X-196423)
- Rocuronium Impurity 40 (CAS CATO-C4X-124240)
- Nintedanib Impurity 1 (CAS 2410284-89-6)
- 2-(Bromomethyl)-1-methoxy-4-(propan-2-yl)benzene (CAS 167887-88-9)
- 6-Bromo-3-(dimethylamino)-1,2,3,4-tetrahydro-9H-carbazole (CAS 186545-33-5)
- (S)-2-(1-Isopropylpyrrolidin-2-yl)ethanamine (CAS 681247-82-5)
- 2,4-Dichloro-N-(furan-2-ylmethylene)aniline (CAS 81335-99-1)
- 1-(3-(Trifluoromethyl)phenyl)-1h-imidazole-5-carboxylic acid (CAS 1779124-23-0)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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