Betahistine Impurity 01 DiHCl CAS 101252-40-8
| CAS No. | 101252-40-8 |
| Molecular Formula | C8H12N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Betahistine Impurity 01 DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Betahistine Impurity 01 DiHCl (CAS 101252-40-8, C8H12N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Betahistine Impurity 01 DiHCl (C8H12N2HCl) contains a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H12N2 2*HCl |
| Molecular Weight | 172.66 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Betahistine Standards
- Betahistine EP Impurity A (CAS 100-69-6)
- Betahistine EP Impurity B (CAS 103-74-2)
- Betahistine Impurity 12 (CAS 109-06-8)
- Betahistine impurity 41 (CAS 113985-59-4)
- Betahistine Impurity 45 (CAS 128225-22-9)
- Betahistine impurity 33 (CAS 13585-92-7)
- Betahistine Impurity 13 HCl (CAS 13585-92-7（free base）)
- Betahistine Hydrochloride (CAS 15430-48-5)
Recommended Standards
- Finerenone Impurity 194 (CAS CATO-C4X-2880194)
- Mavacamten Impurity 5 (CAS 1642288-64-9)
- Topiroxostat impurity 71 (CAS CATO-C4X-105571)
- 1-(4-(2,5-Dichlorophenyl)thiazol-2-yl)guanidine (CAS 886497-65-0)
- 4-Allyl-1-fluoro-2-methoxybenzene (CAS 1256479-13-6)
- 2-chloro-N-[phenyl(thien-2-yl)methyl]acetamide (CAS 923709-46-0)
- 1-[(3-methoxyphenyl)methyl]-1h-1,3-benzodiazol-2-amine (CAS 141472-91-5)
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