Betahistine impurity 33 CAS 13585-92-7
| CAS No. | 13585-92-7 |
| Molecular Formula | C8H12N2O |
| Molecular Weight | 152.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Betahistine impurity 33 (CAS 13585-92-7, C8H12N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Betahistine impurity 33 (C8H12N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 152.19 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Betahistine impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12N2O |
| Molecular Weight | 152.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Nitrogen Atoms | 2 |
Related Betahistine Standards
- Betahistine impurity N3 (CAS 562101-24-0)
- Betahistine impurity 41 (CAS 113985-59-4)
- Betahistine Impurity 22 (CAS 49745-42-8)
- Betahistine Impurity 27 (CAS 26832-29-1)
- Betahistine Impurity 03 (CAS 88780-61-4)
- Betahistine Impurity 19 (CAS 32635-81-7)
- Betahistine impurity 37 (CAS CATO-C4X-183837)
- Betahistine impurity 38 (CAS CATO-C4X-183838)
Recommended Standards
- Tiotropium Bromide Impurity 32 (CAS 1570-95-2)
- 4-Methoxyphenethyl Alcohol (CAS 702-23-8)
- Cefmetazole Impurity 48 (CAS 310466-38-7)
- Metaraminol Impurity 37 (CAS 55789-02-1)
- Sorafenib Impurity 62 (CAS CATO-C4X-112462)
- Losartan Impurity 45 (CAS 141949-90-8)
- Chlorpromazine Impurity 19 (CAS CATO-C4X-142119)
- 6-Chloro-5-methylnicotinamide (CAS 65169-44-0)
- (4R,5R)-5-Amino-2,2-dimethyloxan-4-ol (CAS 1707290-45-6)
- Protoporphyrin IX Impurity 1 (CAS 130851-16-0)
- methyl 4-aminopyrrolo[2,1-f][1,2,4]triazine-2-carboxylate (CAS 2091941-63-6)
- 3-Chloro-4-cyclopropyl-2-methoxyaniline (CAS 2866291-69-0)
- Ethyl 3-bromo-4-cyano-5-methylbenzoate (CAS 1805580-63-5)
- Semaglutide Impurity 163 (x TFA Salt) (CAS CATO-C4X-2226163)
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