n-(5-Amino-2-methoxyphenyl)-4-chloro-2-fluorobenzamide CAS 1016696-80-2
| CAS No. | 1016696-80-2 |
| Molecular Formula | C14H12ClFN2O2 |
| Molecular Weight | 294.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 294.71 g/mol gives n-(5-Amino-2-methoxyphenyl)-4-chloro-2-fluorobenzamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies n-(5-Amino-2-methoxyphenyl)-4-chloro-2-fluorobenzamide (CAS 1016696-80-2), a certified reference material (molecular formula C14H12ClFN2O2, MW 294.71 g/mol) for analytical method development and quality control.
The molecular framework of n-(5-Amino-2-methoxyphenyl)-4-chloro-2-fluorobenzamide (C14H12ClFN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), n-(5-Amino-2-methoxyphenyl)-4-chloro-2-fluorobenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12ClFN2O2 |
| Molecular Weight | 294.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related n Standards
- N-(5-Amino-2-chlorophenyl)-2-(3-fluorophenoxy)-acetamide (CAS 1096336-47-8)
- N-(3-Amino-4-chlorophenyl)-2-(3-fluorophenoxy)-acetamide (CAS 954575-59-8)
- N-(4-amino-2-chlorophenyl)-2-(3-fluorophenoxy)acetamide (CAS 953747-30-3)
- N-(5-Amino-2-fluorophenyl)-2-(2-chlorophenoxy)-acetamide (CAS 953739-94-1)
- N-(5-Amino-2-fluorophenyl)-2-(4-chlorophenoxy)-acetamide (CAS 954271-66-0)
- 2-Amino-4-(4-chlorophenyl)thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione (CAS 898131-77-6)
- Methyl 5-(5-amino-4-carbamoyl-1H-pyrazol-1-yl)-2-chlorobenzoate (CAS 1708269-23-1)
- 3-Amino-3-(5-(3-chloro-4-methoxyphenyl)furan-2-yl)propanamide (CAS 771522-93-1)
Recommended Standards
- Triflumizole-amino (CAS 131549-75-2)
- 4-Chloro-n-(2-methoxyethyl)-2-nitrobenzenesulfonamide (CAS 1089581-75-8)
- n-(4-Chloro-2-(trifluoromethyl)phenyl)-2-(isopropylamino)acetamide (CAS 900641-79-4)
- 2-((2-Chloro-4-fluorobenzyl)oxy)-5-methoxybenzaldehyde (CAS 1094483-22-3)
- Reversin 205 (CAS 174630-05-8)
- N-(benzo[d]thiazol-2-yl)-4-chlorobenzenesulfonamide (CAS 35607-93-3)
- N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine hydrochloride (CAS 524722-52-9)
- 2-((2-Chloroethyl)sulfonyl)-5-(trifluoromethyl)pyridine (CAS 243643-97-2)
- 2-Bromo-3-chlorobenzenesulfonamide (CAS 1261499-12-0)
- 2’,6’-Dimethylbiphenyl-3-carbaldehyde (CAS 691905-26-7)
- 7-Methylbenzo[d]isothiazole (CAS 1352891-75-8)
- 2,6-Dibromonicotinoyl chloride (CAS 1379342-33-2)
- 1049701-64-5 2,2-Dihydroxy-1H-benz[F]indene-1,3(2H)-dione, Hydrate 2,2-Dihydroxybenz[f]indane-1,3-dione Hydrate Benzo[f]ninhydrin Hydrate (CAS 1049701-64-5)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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