Ethyl 2-(3-cyclopropyl-6-hydroxy-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate CAS 1018142-74-9
| CAS No. | 1018142-74-9 |
| Molecular Formula | C14H14F3N3O3 |
| Molecular Weight | 329.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ethyl 2-(3-cyclopropyl-6-hydroxy-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ethyl 2-(3-cyclopropyl-6-hydroxy-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1018142-74-9), a certified reference material (molecular formula C14H14F3N3O3, MW 329.27 g/mol) for analytical method development and quality control.
Ethyl 2-(3-cyclopropyl-6-hydroxy-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (C14H14F3N3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Ethyl 2-(3-cyclopropyl-6-hydroxy-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H14F3N3O3 |
| Molecular Weight | 329.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- 2-(2-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)-1-(3,5-dimethyl-1H-pyrazol-1-yl)ethan-1-one (CAS 1325305-97-2)
- 2-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethoxy)pyridine (CAS 1355071-91-8)
- (E)-1-(4-(5-Cyclopropyl-1,3,4-oxadiazol-2-yl)piperidin-1-yl)-3-(thiophen-2-yl)prop-2-en-1-one (CAS 1211932-10-3)
- N-Cyclopropyl-N-(2-(thiophen-2-yl)ethyl)benzo[c][1,2,5]thiadiazole-5-carboxamide (CAS 1396853-70-5)
- N-((5-Cyclopropyl-1-methyl-1H-pyrazol-3-yl)methyl)-1-(thiophen-2-yl)cyclopentane-1-carboxamide (CAS 1448072-26-1)
- N-Cyclopropyl-5-iodo-6-(trifluoromethyl)pyrimidin-4-amine (CAS 1706464-33-6)
- N-Cyclopropyl-3-(4-(methylthio)phenyl)-N-(thiophen-3-ylmethyl)acrylamide (CAS 1798402-07-9)
- N-Cyclopropyl-N-(2-(thiophen-2-yl)ethyl)benzo[d]thiazole-2-carboxamide (CAS 1396714-70-7)
Recommended Standards
- U-47700 (CAS 82657-23-6)
- 2-((Benzyloxy)carbonyl)-4-(trifluoromethyl)-2-azabicyclo[2.1.1]hexane-1-carboxylic acid (CAS 1050886-63-9)
- N-(2,2,2-Trifluoro-1,1-bis(4-fluorophenyl)ethyl)acetamide (CAS 2247-78-1)
- Methyl 5-isopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole-4-carboxylate (CAS 1097776-52-7)
- (2'-Fluoro-[1,1'-biphenyl]-3-yl)methanamine (CAS 600735-62-4)
- 2-Chloro-n-[(furan-2-yl)methyl]quinazolin-4-amine (CAS 70128-51-7)
- Methyl protogracillin (CAS 54522-53-1)
- Methyl 2-(3-fluoro-4-methoxyphenyl)acetate (CAS 588-14-7)
- 2-(Benzyl(ethyl)amino)-N-(prop-2-yn-1-yl)acetamide (CAS 1181555-64-5)
- 6-Amino-5-ethyl-2-morpholinopyrimidin-4(3h)-one (CAS 1339017-82-1)
- 4-(Chloromethyl)-2-(4-ethoxyphenyl)-1,3-thiazole (CAS 147046-35-3)
- Bromfenac Impurity 27 (CAS CATO-C4X-200227)
- 1-Ethyl 2-aminopropanedioate (CAS 91469-69-1)
- D-Ile17-Tirzepatide (CAS CATO-CPTD788917)
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