6-Chloro-2,3-dimethyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridine CAS 1018165-26-8

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Chloro-2,3-dimethyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridine.

6-Chloro-2,3-dimethyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridine (CAS 1018165-26-8) is a high-purity analytical reference standard with the molecular formula C9H7ClF3N3 and a molecular weight of 249.62 g/mol.

The molecular framework of 6-Chloro-2,3-dimethyl-4-(trifluoromethyl)-2h-pyrazolo[3,4-b]pyridine (C9H7ClF3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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