2-((4-(Difluoromethyl)-2-ethyl-2h-pyrazolo[3,4-b]pyridin-6-yl)thio)acetic acid CAS 1018166-37-4
| CAS No. | 1018166-37-4 |
| Molecular Formula | C11H11F2N3O2S |
| Molecular Weight | 287.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-((4-(Difluoromethyl)-2-ethyl-2h-pyrazolo[3,4-b]pyridin-6-yl)thio)acetic acid (C11H11F2N3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2-((4-(Difluoromethyl)-2-ethyl-2h-pyrazolo[3,4-b]pyridin-6-yl)thio)acetic acid (CAS 1018166-37-4), molecular formula C11H11F2N3O2S and molecular weight 287.29 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-((4-(Difluoromethyl)-2-ethyl-2h-pyrazolo[3,4-b]pyridin-6-yl)thio)acetic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H11F2N3O2S |
| Molecular Weight | 287.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Difluoromethyl Standards
- Methyl 2-((4-(difluoromethyl)-2-methyl-2H-pyrazolo[3,4-b]pyridin-6-yl)thio)acetate (CAS 1018047-37-4)
- Ethyl 7-(difluoromethyl)-5-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 1706459-05-3)
- 2-(4-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1803963-01-0)
- 2-(Difluoromethyl)-3-hydroxy-5-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1804359-32-7)
- 4-(Difluoromethyl)-6-methoxy-5-(trifluoromethoxy)nicotinic acid (CAS 1804479-67-1)
- 2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-acetic acid (CAS 1804798-01-3)
- 2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1804837-46-4)
- 2-(4-(Difluoromethyl)-6-hydroxy-5-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1804837-61-3)
Recommended Standards
- 1-(2-Aminoethyl)-5-(4-fluorobenzyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 1105196-86-8)
- Siponimod impurity 24 (CAS CATO-C4X-247224)
- 1-(2-Aminoethyl)-5-(3-fluorobenzyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 1105196-92-6)
- Ponatinib Impurity 57 (CAS CATO-C4X-226957)
- 2-(P-tolyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS 1031605-70-5)
- 4-Fluoro-N-(2-methylpentan-3-yl)aniline (CAS 1157438-46-4)
- N-(2-Aminoethyl)-N-(2-(phenylsulfonyl)ethyl)isoquinoline-5-sulfonamide (CAS 651309-21-6)
- 2-(6-Nitropyridin-3-yl)acetonitrile (CAS 1936247-74-3)
- Poly(oxy-1,2-ethanediyl), .alpha.-[4-(1,1-dimethylethyl)phenyl]-.omega.-hydroxy- (CAS 18249-20-2)
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