5-(3,4-Difluorophenyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid CAS 1018170-52-9
| CAS No. | 1018170-52-9 |
| Molecular Formula | C10H7F2NO3 |
| Molecular Weight | 227.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-(3,4-Difluorophenyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
5-(3,4-Difluorophenyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid (CAS 1018170-52-9), molecular formula C10H7F2NO3 and molecular weight 227.16 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(3,4-Difluorophenyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid (C10H7F2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H7F2NO3 |
| Molecular Weight | 227.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 3-(2,5-Difluorophenyl)-4,5-dihydro-1,2-oxazole-5-carboxylic acid (CAS 1096348-81-0)
- (E)-4-((2,4-difluorophenyl)amino)-4-oxobut-2-enoic acid (CAS 1164538-71-9)
- 3-(3,5-Difluorophenyl)-4,5-dihydroisoxazole-5-carboxylic acid (CAS 1694094-73-9)
- (Z)-4-((2,4-difluorophenyl)amino)-4-oxobut-2-enoic acid (CAS 6954-64-9)
- 4-((2,4-Difluorophenyl)amino)-4-oxobut-2-enoic acid (CAS 198077-70-2)
- 4-(3,4-Difluorophenyl)pyrrolidine-3-carboxylic acid (CAS 1342031-77-9)
- 4-(2,3-Difluorophenyl)pyrrolidine-3-carboxylic acid (CAS 1343575-62-1)
- (2,3-Difluorophenyl)(morpholino)methanone (CAS 351038-43-2)
Recommended Standards
- 3,3,4,4,4-Pentafluorobutane-1-sulfonamide (CAS 29765-92-2)
- Pyridin-3-yl trifluoromethanesulfonate (CAS 107658-27-5)
- 2-Octyl-1,3,6,2-dioxazaborocane (CAS 96508-56-4)
- 2,4-dichloro-7-methylthieno[3,2-d]pyrimidine (CAS 35265-83-9)
- 3-Methoxy-2-(tributylstannyl)pyridine (CAS 1094072-15-7)
- 4,4'-(Butane-2,2-diyl)bis(2-methylphenol) (CAS 6420-65-1)
- tert-Butyl (2-(benzyloxy)pyridin-4-yl)carbamate (CAS 2173108-35-3)
- 2-Cyclopentylazetidine hydrochloride (CAS 2126159-82-6)
- Ethyl (3-amino-1H-1,2,4-triazole-1-carbonothioyl)glycinate (CAS 338773-85-6)
- 1-(4-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-2-ol (CAS 35808-65-2)
- Fenoterol EP Impurity A (S, R-Isomer) (CAS 391234-95-0)
- Bis-PEG1-NHS ester (CAS 65869-64-9)
- Ethyl 5-amino-4-bromo-1-cyclohexyl-1H-pyrazole-3-carboxylate (CAS 1427021-84-8)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
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