Butenafine Impurity 5 CAS 101828-08-4
| CAS No. | 101828-08-4 |
| Molecular Formula | C22H25N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 339.91 g/mol gives Butenafine Impurity 5 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Butenafine Impurity 5 (CAS 101828-08-4, C22H25NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Butenafine Impurity 5 (C22H25NHCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H25N HCl |
| Molecular Weight | 339.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Butenafine Standards
- Butenafine Hydrochloride (CAS 101827-46-7)
- Butenafine Impurity 4 (CAS 101827-53-6)
- Butenafine (CAS 101828-21-1)
- Butenafine Impurity 8 (CAS 110931-65-2)
- Butenafine Impurity 11 (CAS 110951-99-0)
- Butenafine Impurity 3 (CAS 122152-13-0)
- Butenafine Impurity 14 (CAS 124830-38-2)
- Butenafine Impurity 31 (CAS 141788-33-2)
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