5-(Chlorosulfonyl)thiophene-2-carboxylic acid CAS 10216-12-3
| CAS No. | 10216-12-3 |
| Molecular Formula | C5H3ClO4S2 |
| Molecular Weight | 226.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(Chlorosulfonyl)thiophene-2-carboxylic acid is closely related to a carbohydrate-derived structure, a sulfone group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(Chlorosulfonyl)thiophene-2-carboxylic acid (CAS 10216-12-3), molecular formula C5H3ClO4S2 and molecular weight 226.66 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carbohydrate-derived structure, a sulfone group, chlorine substitution, 5-(Chlorosulfonyl)thiophene-2-carboxylic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 226.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(Chlorosulfonyl)thiophene-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H3ClO4S2 |
| Molecular Weight | 226.66 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 2 |
Related Chlorosulfonyl Standards
- 4-(Chlorosulfonyl)thiophene-3-carboxylic acid (CAS 1375472-54-0)
- 3-(Chlorosulfonyl)thiophene-2-carboxylic acid (CAS 741653-98-5)
- 4-(Chlorosulfonyl)thiophene-2-carboxylic acid (CAS 79279-54-2)
- 5-(Chlorosulfonyl)thiophene-3-carboxylic acid (CAS 875163-07-8)
- 4-(Chlorosulfonyl)benzoic acid (CAS 10130-89-9)
- 3-[(chlorosulfonyl)(2-methoxyethyl)amino]propanenitrile (CAS 1343675-60-4)
- Ethyl 2-(1-(chlorosulfonyl)cyclopropyl)acetate (CAS 1461708-73-5)
- methyl 2-(chlorosulfonyl)cyclopentane-1-carboxylate (CAS 1552637-43-0)
Recommended Standards
- 2-chloro-6-(cyclopropylmethoxy)benzoic acid (CAS 1020934-87-5)
- (3-Chloro-5-methoxy-4-(prop-2-yn-1-yloxy)phenyl)methanol (CAS 1030765-35-5)
- 5-Chloro-6-(pyrrolidin-1-yl)nicotinic acid (CAS 1019127-02-6)
- 3-(4-Chlorophenyl)tetrahydrofuran-3-carboxylic acid (CAS 1035261-04-1)
- N,N'-((1R,2R)-Cyclohexane-1,2-diyl)bis(1-(pyridin-2-yl)methanimine) (CAS 92760-39-9)
- O-(2-Phenoxyethyl)hydroxylamine (CAS 73941-29-4)
- 1-Oxa-7-azaspiro[3.5]nonane oxalate (CAS 1408076-14-1)
- 3-Hydroxy-4-iodoquinoline-7-carboxylic acid (CAS 2866497-97-2)
- 4-Propionyl-N-(2-(pyridin-2-yl)ethyl)-1H-pyrrole-2-carboxamide (CAS 478259-53-9)
- 1-(4-bromophenyl)-2-methyl-propane-1,2-diol (CAS 612070-23-2)
- 2-(Pyridin-4-yl)acetaldehyde (CAS 878499-08-2)
- 2,5-Dibromo-N-(pyridin-3-yl)benzenesulfonamide (CAS 333444-41-0)
- 1-(1,1-Dibutoxyethoxy)butane (CAS 29633-71-4)
- Acetyl-(Leu28·31)-Neuropeptide Y (24-36) (CAS 155709-24-3)
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