ethyl 2-cyano-2-(2-fluorophenyl)acetate CAS 102276-85-7
| CAS No. | 102276-85-7 |
| Molecular Formula | C11H10FNO2 |
| Molecular Weight | 207.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
ethyl 2-cyano-2-(2-fluorophenyl)acetate (CAS 102276-85-7), molecular formula C11H10FNO2 and molecular weight 207.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of ethyl 2-cyano-2-(2-fluorophenyl)acetate (C11H10FNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), ethyl 2-cyano-2-(2-fluorophenyl)acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H10FNO2 |
| Molecular Weight | 207.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related ethyl Standards
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- Ethyl 2-cyano-2-(4-fluorophenyl)acetate (CAS 15032-42-5)
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- 2-(4-Cyano-2-methoxyphenoxy)acetic acid (CAS 115109-49-4)
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- 2-Chloro-5-(pyrrolidine-1-sulfonyl)benzoic acid (CAS 151104-21-1)
- Dronedarone-d6 HCl (CAS 1329809-23-5)
- 1-(3-Amino-5-methoxypyridin-2-yl)ethan-1-one (CAS 1393572-12-7)
- Atrasentan Impurity 127 (CAS 1063835-98-2)
- Semaglutide impurity 196 (CAS CATO-C4X-2226196)
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