4-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-N-(4-methoxyphenyl)-1,3-thiazol-2-amine CAS 1024375-85-6
| CAS No. | 1024375-85-6 |
| Molecular Formula | C22H15ClF3N3O2S |
| Molecular Weight | 477.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-N-(4-methoxyphenyl)-1,3-thiazol-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 4-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-N-(4-methoxyphenyl)-1,3-thiazol-2-amine (CAS 1024375-85-6), a certified reference material (molecular formula C22H15ClF3N3O2S, MW 477.89 g/mol) for analytical method development and quality control.
The molecular framework of 4-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-N-(4-methoxyphenyl)-1,3-thiazol-2-amine (C22H15ClF3N3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H15ClF3N3O2S |
| Molecular Weight | 477.89 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related chloro Standards
- 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)phenyl naphthalene-2-sulfonate (CAS 338415-85-3)
- N-{[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}-4-fluoro-N-(4-methoxyphenyl)benzene-1-sulfonamide (CAS 955975-51-6)
- (2E)-1-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-2-phenyl-3-(thiophen-2-yl)prop-2-en-1-one (CAS 478079-01-5)
- 2-((5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidin-2-yl)thio)-1-(3-(trifluoromethyl)phenyl)ethan-1-one (CAS 344263-28-1)
- 7-Chloro-N-(4-isopropylphenyl)-3-(phenylsulfonyl)-[1,2,3]triazolo[1,5-a]quinazolin-5-amine (CAS 893787-13-8)
- 1-{4-[(2-chloro-1,3-thiazol-5-yl)methoxy]benzenesulfonyl}-4-(2,5-dimethylphenyl)piperazine (CAS 860784-39-0)
- N-(4-Chloro-2-methoxy-5-methylphenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 578759-27-0)
- (2E)-3-[(4-Chloro-3-nitrophenyl)amino]-1-{3-[(2,4-dichlorophenyl)methoxy]phenyl}prop-2-en-1-one (CAS 478040-27-6)
Recommended Standards
- Chlortetracycline EP Impurity H (CAS 7301-38-4)
- GS-9901, >98% (HPLC) (CAS 1640247-87-5)
- N-(9-((2R,3R,4R,5R)-3-(1-(2-Chloroethoxy)ethoxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 138078-24-7)
- VR23 (CAS 1624602-30-7)
- 4-Bromopyrimidin-2(1H)-one (CAS 548767-83-5)
- thiomalononitrile (CAS 111-97-7)
- 2-(3,4-Dihydronaphthalen-2-yl)acetic acid (CAS 54154-71-1)
- 3-Methylcyclobutanol (CAS 20939-64-4)
- 3,5-Difluoro-2-(trifluoromethyl)pyridine (CAS 1099598-21-6)
- 2-Isopropyl-1-methyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid (CAS 1521626-83-4)
- 3-Chloropropan-1-amine (CAS 14753-26-5)
- 1-(3-((Iodotriphenylphosphoranyl)(methyl)amino)phenyl)ethanone (CAS 88540-73-2)
- (4-Trifluoromethyl-piperidin-1-yl)-acetonitrile (CAS 1416352-13-0)
- Delicious Peptide (bovine) (CAS 73984-05-1)
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