N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide CAS 1025720-94-8
| CAS No. | 1025720-94-8 |
| Molecular Formula | C25H19ClF2N4O4 |
| Molecular Weight | 512.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide.
N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide (CAS 1025720-94-8), molecular formula C25H19ClF2N4O4 and molecular weight 512.89 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide (C25H19ClF2N4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 17.0, corresponding to approximately 17 ring(s) or double-bond equivalent(s). With a molecular weight of 512.89 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H19ClF2N4O4 |
| Molecular Weight | 512.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
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Recommended Standards
- Triphenylantimony dibromide, 98+% (CAS 1538-59-6)
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- 5-Acetyl-1-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-3-(2-(4-methoxyphenoxy)ethyl)pyrimidine-2,4(1H,3H)-dione (CAS 338399-62-5)
- 1-[4-chloro-3-(trifluoromethyl)benzenesulfonyl]-4-[4-(5-methyl-1H-pyrazol-1-yl)benzoyl]piperazine (CAS 1007647-73-5)
- 4-methyl-3-(1-methyl-1H-pyrazol-4-yl)benzoic acid hydrochloride (CAS 2060006-85-9)
- N-(2-Cyano-3-methylbutan-2-yl)-2-((5-((2-ethoxyphenyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 742116-33-2)
- 25,26,26,26,27,27,27-Heptafluoro-5,6-epoxycholestanol (CAS 240129-24-2)
- N-[(5-Fluoro-2-nitrophenyl)methyl]acetamide (CAS 2140316-94-3)
- 1-Methyl-1,2,3,4-tetrahydroquinoxaline-5-carbonitrile (CAS 115661-91-1)
- 3-[(furan-2-ylmethyl)amino]-4-hydroxy-1lambda6-thiolane-1,1-dione (CAS 302806-16-2)
- N-(2-{[2,5-bis(2,2,2-trifluoroethoxy)phenyl]formamido}ethyl)acetamide (CAS 338404-45-8)
- 4-(2,3-Dimethylphenyl)piperidin-4-ol hydrochloride (CAS 1354960-07-8)
- 1-Benzyl-3-(4-ethylphenyl)-1h-pyrazole-4-carboxylic acid (CAS 956386-81-5)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
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