Ibuprofen Impurity 20 CAS 10262-65-4
| CAS No. | 10262-65-4 |
| Molecular Formula | C13H11BrO2 |
| Molecular Weight | 279.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C13H11BrO2, Ibuprofen Impurity 20 contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 279.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Ibuprofen Impurity 20 (CAS 10262-65-4, C13H11BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11BrO2 |
| Molecular Weight | 279.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Br-containing |
Related Ibuprofen Standards
- Ibuprofen Impurity 149 (CAS CATO-C4X-1082149)
- Ibuprofen 2,3-Butylene Glycol Ester (CAS 95093-59-7)
- Ibuprofen impurity 123 (CAS CATO-C4X-1082123)
- Ibuprofen impurity 124 (CAS CATO-C4X-1082124)
- Ibuprofen Impurity 83 (CAS 64622-21-5)
- Ibuprofen Impurity 100 (CAS CATO-C4X-1082100)
- Ibuprofen Impurity 91 (CAS CATO-C4X-108291)
- Ibuprofen Impurity 110 (CAS CATO-C4X-1082110)
Recommended Standards
- 52376-16-6 1,4-Diacetoxy-2-bromobenzene DTXSID50391036 (CAS 52376-16-6)
- 3-(2-Methoxyethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1010104-34-3)
- 51760-21-5 Dimethyl 5-bromoisophthalate 1,3-Benzenedicarboxylic acid, 5-bromo-, 1,3-dimethyl ester 1,3-Benzenedicarboxylic acid, 5-bromo-, dimethyl ester 5-Bromoisophthalic acid, dimethyl ester EINECS 257-386-0 (CAS 51760-21-5)
- 2-(Dimethoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1150632-93-1)
- Eravacycline Impurity 10 (CAS 1207283-60-0)
- Sitafloxacin impurity 90 (CAS 112062-51-8)
- Aceclofenac Impurity 17 (CAS CATO-C4X-153117)
- Tacrolimus 15-DMT (CAS 151039-41-7)
- 5-(1-Aminoethyl)3-pyridinecarboxylic acid methyl ester (CAS 38940-68-0)
- ({6-chloroimidazo[2,1-b][1,3]thiazol-5-yl}methyl)(methyl)amine (CAS 1000930-88-0)
- n-((1h-Pyrazol-3-yl)methyl)-3,4-difluoroaniline (CAS 1006438-41-0)
- 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate (CAS 109028-10-6)
- Cholic Acid Impurity 88 (CAS CATO-C4X-116088)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
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